RPS3A and PARP1

Number of citations of the paper that reports this interaction (PubMedID 11790116)
0

Data Source:
HPRD (two hybrid, in vitro)

		RPS3A	PARP1
Description		ribosomal protein S3A	poly(ADP-ribose) polymerase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Synapse Extracellular Exosome Ribonucleoprotein Complex	Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Nuclear Replication Fork Site Of DNA Damage
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding	DNA Binding Chromatin Binding Damaged DNA Binding RNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Nucleosome Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Transcription Regulator Activator Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Cytoplasmic Translation Translation Translational Initiation Cell Differentiation Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Immune System Process DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Carbohydrate Biosynthetic Process Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Mitochondrial DNA Repair Innate Immune Response Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Necroptotic Process Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Cellular Response To Zinc Ion Cellular Response To Transforming Growth Factor Beta Stimulus Replication Fork Reversal DNA Repair-dependent Chromatin Remodeling Negative Regulation Of CGAS/STING Signaling Pathway Transcription Pausing By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen-containing Compound Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Aldosterone Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Regulation Of Base-excision Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Site Of Double-strand Break ATP Generation From Poly-ADP-D-ribose Negative Regulation Of ATP Biosynthetic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		HDL cholesterol ( 20686565)	Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785 32109421) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480 32341527) Platelet count ( 29403010) Telomere length ( 29151059)
Interacting Genes		23 interacting genes: ATF7IP CCDC50 CHN1 CREB3 CSTPP1 DDIT3 DUX4 EDEM2 FANCC FNDC3B HGS HSP90AA1 LINC01232 NEDD4 OGT PARP1 SAP18 SOD2 TOE1 UBE2I UBXN7 USP40 VDAC2	123 interacting genes: AATF ANXA1 APTX ATM ATR BCL2 BGLT3 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CEBPA CENPA CENPB CTCF CTSB CTSG DTX2 DUX4 E2F1 E4F1 EPB41L2 ERBB2 ERCC6 ERG ETS1 FNDC3B FOXO1 GTF2F1 GZMB GZMM H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-4 H4C3 HDAC1 HDAC3 HECTD3 HIPK2 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MALAT1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF10 RNF144A RNF168 RNF4 RPS3A RSPH1 RXRA SENP1 SENP3 SMURF2 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I USP1 USP15 USP7 WEE2-AS1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		6189	142
HPRD ID		01606	01435
Ensembl ID		ENSG00000145425	ENSG00000143799
Uniprot IDs		B7Z3M5 P61247	P09874
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6 7ONR 7ONS 7ONT 7S68 7S6H 7S6M 7S81 7SCY 7SCZ 8FYY 8FYZ 8FZ1 8G0H 8HE7 8HLR 8JNZ 8U4W 9BPY 9CKC 9DMC 9ETQ 9ETR
Enriched GO Terms of Interacting Partners?		Nuclear Body Response To Unfolded Protein Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Regulator Activator Activity Proteolysis Endoplasmic Reticulum Unfolded Protein Response CAMP Response Element Binding Protein Binding Protein Localization To Lysosome Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytosol Protein Localization To Vacuole Ubiquitin Binding Protein Localization To Organelle NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Necroptotic Process Cellular Response To Stress Ubiquitin Protein Ligase Binding Cellular Response To Chemical Stress Negative Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Contraction Establishment Of Protein Localization To Organelle Integrated Stress Response Signaling CTP Binding DATP Binding Regulation Of Protein Catabolic Process Mitochondrial Transport Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Intracellular Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Postsynaptic Cytosol Protein Targeting To Lysosome Viral Process Formation Of Structure Involved In A Symbiotic Process Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity	Nucleoplasm Nucleus DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Chromosome Protein Modification Process Negative Regulation Of DNA Metabolic Process DNA Repair DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Chromatin Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Negative Regulation Of Cell Cycle Protein Localization To Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Transcription Regulator Complex
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