RPS3A and CHN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS3A	CHN1
Gene Name		ribosomal protein S3A	chimerin 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome	Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	SH3/SH2 Adaptor Activity GTPase Activator Activity Metal Ion Binding Ephrin Receptor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process	Small GTPase Mediated Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)
Protein-Protein Interactions		15 interactors: ATF7IP C11orf49 CCDC50 CHN1 DDIT3 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 VDAC2	12 interactors: ACVR1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1
Entrez ID		6189	1123
HPRD ID		01606	00319
Ensembl ID		ENSG00000145425	ENSG00000128656
Uniprot IDs		B7Z3M5 P61247	P15882
PDB IDs		3J3A	2OSA 3CXL
Enriched GO Terms of Interacting Partners?		Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Cellular Response To Reactive Oxygen Species Protein Targeting To Lysosome Reactive Oxygen Species Metabolic Process Protein Localization To Lysosome Removal Of Superoxide Radicals Response To Unfolded Protein Cellular Response To Stress Positive Regulation Of Metabolic Process Protein Targeting To Vacuole Response To Inorganic Substance Establishment Of Protein Localization To Vacuole Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Superoxide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Lysosomal Transport Regulation Of Signaling Negative Regulation Of Gene Expression Cytoplasmic Transport Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To DNA Damage Stimulus Establishment Of Protein Localization To Organelle Vacuolar Transport Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development	Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Peptidyl-threonine Phosphorylation Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Neuron Differentiation Axon Guidance Positive Regulation Of Protein Phosphorylation Cell Development Locomotion Regulation Of Kinase Activity Regulation Of Phosphorylation Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Generation Of Neurons Positive Regulation Of Transferase Activity Signal Transduction By Phosphorylation Axon Development Cell Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Serine Phosphorylation Of STAT3 Protein Cell Motility Nervous System Development Regulation Of Cell Death Serine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation
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