RPS3A and EDEM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS3A	EDEM2
Gene Name		ribosomal protein S3A	ER degradation enhancer, mannosidase alpha-like 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process	Protein Folding Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) ER Quality Control Compartment (ERQC) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS		HDL cholesterol ( 20686565)	Hemostatic factors and hematological phenotypes ( 22443383) Protein C levels ( 20802025) Prothrombin time ( 22703881)
Protein-Protein Interactions		15 interactors: ATF7IP C11orf49 CCDC50 CHN1 DDIT3 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 VDAC2	1 interactors: RPS3A
Entrez ID		6189	55741
HPRD ID		01606	09841
Ensembl ID		ENSG00000145425	ENSG00000088298
Uniprot IDs		B7Z3M5 P61247	Q9BV94
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Cellular Response To Reactive Oxygen Species Protein Targeting To Lysosome Reactive Oxygen Species Metabolic Process Protein Localization To Lysosome Removal Of Superoxide Radicals Response To Unfolded Protein Cellular Response To Stress Positive Regulation Of Metabolic Process Protein Targeting To Vacuole Response To Inorganic Substance Establishment Of Protein Localization To Vacuole Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Negative Regulation Of Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Superoxide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Lysosomal Transport Regulation Of Signaling Negative Regulation Of Gene Expression Cytoplasmic Transport Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To DNA Damage Stimulus Establishment Of Protein Localization To Organelle Vacuolar Transport Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Neuron Development	Cytoplasmic Translation Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Targeting To Membrane Translational Elongation RNA Catabolic Process Cellular Protein Complex Disassembly Viral Life Cycle Protein Complex Disassembly Establishment Of Protein Localization To Membrane Translational Initiation
Tagcloud ?			catalyzes check controversy destruction edem1 edem3 edems elusive evolving glycoproteins gperad homologue homologues htm1 lectins lesser limiting man7glcnac2 man8glcnac2 man9glcnac2 mannose mannosidase mannosidases misfolded nuclease oligosaccharide possess surprisingly trimming
Tagcloud (Difference) ?			catalyzes check controversy destruction edem1 edem3 edems elusive evolving glycoproteins gperad homologue homologues htm1 lectins lesser limiting man7glcnac2 man8glcnac2 man9glcnac2 mannose mannosidase mannosidases misfolded nuclease oligosaccharide possess surprisingly trimming
Tagcloud (Intersection) ?