RPS3A and SOD2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS3A	SOD2
Description		ribosomal protein S3A	superoxide dismutase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Small-subunit Processome Synapse Extracellular Exosome Ribonucleoprotein Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding	DNA Binding Superoxide Dismutase Activity Protein Binding Oxidoreductase Activity Oxygen Binding Enzyme Binding Manganese Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Translation Translational Initiation Cell Differentiation Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process	Response To Reactive Oxygen Species Response To Superoxide Response To Hypoxia Release Of Cytochrome C From Mitochondria Liver Development Detection Of Oxygen Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Superoxide Metabolic Process Response To Oxidative Stress Mitochondrion Organization Heart Development Locomotory Behavior Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Xenobiotic Stimulus Post-embryonic Development Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Response To Gamma Radiation Positive Regulation Of Hydrogen Peroxide Biosynthetic Process Response To Activity Removal Of Superoxide Radicals Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Response To Nutrient Levels Intracellular Oxygen Homeostasis Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Silicon Dioxide Cellular Response To Oxidative Stress Response To Isolation Stress Response To Immobilization Stress Vasodilation Response To Hydrogen Peroxide Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Response To Cadmium Ion Negative Regulation Of Fibroblast Proliferation Neuron Development Response To Axon Injury Erythrophore Differentiation Hydrogen Peroxide Biosynthetic Process Protein Homotetramerization Response To Electrical Stimulus Regulation Of Mitochondrial Membrane Potential Response To Hyperoxia Multicellular Organismal-level Iron Ion Homeostasis Response To Magnetism Cellular Response To Ethanol Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Membrane Hyperpolarization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Mitochondrial unfolded protein response (UPRmt)
Drugs			Benzylsulfonic acid 3-Fluoro-L-tyrosine Benzoyl peroxide
Diseases
GWAS		HDL cholesterol ( 20686565)	Age-related macular degeneration (geographic atrophy) ( 22705344) Erosive tooth wear (severe vs non-severe) ( 29898447) Lipoprotein (a) levels ( 26377243) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Polycystic ovary syndrome ( 32289280) Pulse pressure ( 27841878)
Interacting Genes		23 interacting genes: ATF7IP CCDC50 CHN1 CREB3 CSTPP1 DDIT3 DUX4 EDEM2 FANCC FNDC3B HGS HSP90AA1 LINC01232 NEDD4 OGT PARP1 SAP18 SOD2 TOE1 UBE2I UBXN7 USP40 VDAC2	9 interacting genes: APP CEP70 CYP4F12 GET4 HDHD2 KIAA1549 NOL12 RAB4A RPS3A
Entrez ID		6189	6648
HPRD ID		01606	00938
Ensembl ID		ENSG00000145425	ENSG00000291237
Uniprot IDs		B7Z3M5 P61247	A0A384NL29 G5E9P6 P04179 Q96AM7
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7MQ8 7MQ9 7MQA 7QP6 7QP7 7QVP 7R4X 7TQL 7WTS 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O	1AP5 1AP6 1EM1 1JA8 1LUV 1LUW 1MSD 1N0J 1N0N 1PL4 1PM9 1QNM 1SZX 1VAR 1XDC 1XIL 1ZSP 1ZTE 1ZUQ 2ADP 2ADQ 2GDS 2P4K 2QKA 2QKC 3C3S 3C3T 5GXO 5T30 5VF9 7KKS 7KKU 7KKW 7KLB 8SKS 8VHW 8VHY 8VJ0 8VJ4 8VJ5 8VJ8 9BVY 9BW2 9BWM 9BWQ 9BWR
Enriched GO Terms of Interacting Partners?		Nuclear Body Response To Unfolded Protein Regulation Of Intrinsic Apoptotic Signaling Pathway Transcription Regulator Activator Activity Proteolysis Endoplasmic Reticulum Unfolded Protein Response CAMP Response Element Binding Protein Binding Protein Localization To Lysosome Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytosol Protein Localization To Vacuole Ubiquitin Binding Protein Localization To Organelle NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Necroptotic Process Cellular Response To Stress Ubiquitin Protein Ligase Binding Cellular Response To Chemical Stress Negative Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Skeletal Muscle Contraction Establishment Of Protein Localization To Organelle Integrated Stress Response Signaling CTP Binding DATP Binding Regulation Of Protein Catabolic Process Mitochondrial Transport Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Intracellular Transport Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Postsynaptic Cytosol Protein Targeting To Lysosome Viral Process Formation Of Structure Involved In A Symbiotic Process Acetylcholine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Erythrophore Differentiation SUMO Conjugating Enzyme Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity
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