BCR and IGSF21

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BCR	IGSF21
Description		BCR activator of RhoGEF and GTPase	immunoglobin superfamily member 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Protein-containing Complex Cell Projection Dendritic Spine Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane Cell Junction Presynaptic Membrane Synapse Postsynaptic Membrane Inhibitory Synapse Side Of Membrane Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Phagocytosis Signal Transduction Small GTPase-mediated Signal Transduction Brain Development Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Response To Lipopolysaccharide Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of Neutrophil Degranulation Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Macrophage Migration Negative Regulation Of Macrophage Migration Negative Regulation Of Reactive Oxygen Species Metabolic Process	Synapse Maturation Trans-synaptic Signaling, Modulating Synaptic Transmission
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Imatinib Dasatinib Bosutinib Ponatinib
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)
GWAS		Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)	Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)
Interacting Genes		44 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		613	84966
HPRD ID		01044	11309
Ensembl ID		ENSG00000186716	ENSG00000117154
Uniprot IDs		P11274	Q96ID5
PDB IDs		1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Adhesion Signal Transduction Intracellular Signaling Cassette Cytoplasm Regulation Of Transport Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Non-membrane Spanning Protein Tyrosine Kinase Activity ERBB Signaling Pathway Focal Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Protein Kinase Binding Regulation Of Immune Response Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Domain Specific Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cadherin Binding Regulation Of Protein Localization Insulin-like Growth Factor Receptor Binding Negative Regulation Of Signal Transduction Regulation Of Protein-containing Complex Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphoserine Residue Binding Positive Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of T Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Insulin Receptor Binding Regulation Of T Cell Activation Negative Regulation Of Immune Response Regulation Of Cell-substrate Adhesion
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