BCR and ABL1

Number of citations of the paper that reports this interaction (PMID 1712671)
62

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		BCR	ABL1
Gene Name		breakpoint cluster region	ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytosol Postsynaptic Density Membrane Cell Junction Protein Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Nuclear Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Rac GTPase Activator Activity	Magnesium Ion Binding DNA Binding Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle	B-1 B Cell Homeostasis B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Blood Coagulation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Depolarization Bergmann Glial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Actin Filament Branching Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus
Pathways		Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Role of Abl in Robo-Slit signaling CDO in myogenesis Axon guidance Myogenesis Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs			Adenosine triphosphate Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA MYRISTIC ACID 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib
Diseases
GWAS		Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470)	Response to amphetamines ( 22952603)
Protein-Protein Interactions		44 interactors: ABL1 ABL2 APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 MLLT4 PIK3CG PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	145 interactors: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1B CDON CREB1 CRK CRKL CTNND2 DDB1 DDB2 DOK1 DOK2 DOK3 EGFR ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PIK3R1 PLCG1 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSMA7 PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHD SHE SLC9A2 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRPK2 ST5 STUB1 TERT TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16
Entrez ID		613	25
HPRD ID		01044	01809
Ensembl ID		ENSG00000186716	ENSG00000097007
Uniprot IDs		P11274	P00519 Q59FK4
PDB IDs		1K1F 2AIN	1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Localization Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of Organelle Organization Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Innate Immune Response ERBB Signaling Pathway Immune Response Cellular Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Wound Healing Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Fc Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Stimulus Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Cell Surface Receptor Signaling Pathway Programmed Cell Death Innate Immune Response Cell Death Death Immune System Process Apoptotic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Immune Response Cell Differentiation Response To Growth Factor Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Defense Response Regulation Of Cellular Component Organization Cell Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Process ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component
Tagcloud ?		absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55	aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding
Tagcloud (Difference) ?		absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55	aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding
Tagcloud (Intersection) ?