BCR and DOK1

Number of citations of the paper that reports this interaction (PubMedID 9822717)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		BCR	DOK1
Description		BCR activator of RhoGEF and GTPase	docking protein 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Protein-containing Complex Cell Projection Dendritic Spine Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Phagocytosis Signal Transduction Small GTPase-mediated Signal Transduction Brain Development Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Response To Lipopolysaccharide Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of Neutrophil Degranulation Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Macrophage Migration Negative Regulation Of Macrophage Migration Negative Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Intracellular Signal Transduction Macrophage Colony-stimulating Factor Signaling Pathway
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs		Imatinib Dasatinib Bosutinib Ponatinib
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)
GWAS		Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)	Bell's palsy ( 33602968) Height ( 31562340)
Interacting Genes		44 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		613	1796
HPRD ID		01044	04228
Ensembl ID		ENSG00000186716	ENSG00000115325
Uniprot IDs		P11274	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		1K1F 2AIN 5N6R 5N7E 5OC7	2V76
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Adhesion Signal Transduction Intracellular Signaling Cassette Cytoplasm Regulation Of Transport Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Non-membrane Spanning Protein Tyrosine Kinase Activity ERBB Signaling Pathway Focal Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Protein Kinase Binding Regulation Of Immune Response Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Domain Specific Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cadherin Binding Regulation Of Protein Localization Insulin-like Growth Factor Receptor Binding Negative Regulation Of Signal Transduction Regulation Of Protein-containing Complex Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphoserine Residue Binding Positive Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of T Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Insulin Receptor Binding Regulation Of T Cell Activation Negative Regulation Of Immune Response Regulation Of Cell-substrate Adhesion	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Cell Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Motility Positive Regulation Of Cell Adhesion Immune Response-regulating Signaling Pathway Protein Kinase Activity Regulation Of Immune Response Protein Phosphorylation Kinase Activity Immune Response-activating Signaling Pathway Plasma Membrane Leukocyte Migration Integrin-mediated Signaling Pathway Phosphorylation Immune System Process Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of Signal Transduction
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