BCR and MAP4K5

Number of citations of the paper that reports this interaction (PMID 9949177)
1

Data Source:
HPRD (in vivo)

		BCR	MAP4K5
Gene Name		breakpoint cluster region	mitogen-activated protein kinase kinase kinase kinase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Postsynaptic Density Membrane Cell Junction Protein Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Rac GTPase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle	Protein Phosphorylation Activation Of JUN Kinase Activity Intracellular Signal Transduction
Pathways		Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470)	Cognitive performance ( 20125193)
Protein-Protein Interactions		44 interactors: ABL1 ABL2 APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 MLLT4 PIK3CG PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	12 interactors: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 TANK TRAF2 ZNF440
Entrez ID		613	11183
HPRD ID		01044	05374
Ensembl ID		ENSG00000186716	ENSG00000012983
Uniprot IDs		P11274	B3KWC4 Q9Y4K4
PDB IDs		1K1F 2AIN
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Localization Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of Organelle Organization Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Innate Immune Response ERBB Signaling Pathway Immune Response Cellular Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Wound Healing Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Fc Receptor Signaling Pathway	Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Innate Immune Response Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Response To Organic Substance Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Endocytosis Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Defense Response Regulation Of Actin Cytoskeleton Organization Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Regulation Of Actin Filament-based Process Regulation Of Phosphorus Metabolic Process Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Organonitrogen Compound Regulation Of Cytoskeleton Organization Positive Regulation Of Innate Immune Response Regulation Of Endocytosis Protein K63-linked Ubiquitination Intracellular Signal Transduction Signal Transduction Positive Regulation Of Interleukin-2 Production Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway
Tagcloud ?		absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Difference) ?		absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Intersection) ?