BCR and VAV1

Number of citations of the paper that reports this interaction (PubMedID 11790798)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		BCR	VAV1
Description		BCR activator of RhoGEF and GTPase	vav guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Membrane Axon Protein-containing Complex Cell Projection Dendritic Spine Synapse Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Phosphorylation-dependent Protein Binding
	Biological Process	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Phagocytosis Signal Transduction Small GTPase-mediated Signal Transduction Brain Development Cell Migration Actin Cytoskeleton Organization Keratinocyte Differentiation Response To Lipopolysaccharide Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of Neutrophil Degranulation Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Macrophage Migration Negative Regulation Of Macrophage Migration Negative Regulation Of Reactive Oxygen Species Metabolic Process	Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Natural Killer Cell Activation Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus Reactive Oxygen Species Metabolic Process
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS Azathioprine ADME Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Imatinib Dasatinib Bosutinib Ponatinib
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)
GWAS		Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369) Left-handedness ( 32989287)	Blood protein levels ( 30072576) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		44 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	80 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CFTR CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		613	7409
HPRD ID		01044	01284
Ensembl ID		ENSG00000186716	ENSG00000141968
Uniprot IDs		P11274	A0A0A0MR07 B2R8B5 P15498 Q96D37
PDB IDs		1K1F 2AIN 5N6R 5N7E 5OC7	2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cytosol Regulation Of Cell Adhesion Signal Transduction Intracellular Signaling Cassette Cytoplasm Regulation Of Transport Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Receptor Tyrosine Kinase Binding Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Non-membrane Spanning Protein Tyrosine Kinase Activity ERBB Signaling Pathway Focal Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Protein Kinase Binding Regulation Of Immune Response Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Domain Specific Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cadherin Binding Regulation Of Protein Localization Insulin-like Growth Factor Receptor Binding Negative Regulation Of Signal Transduction Regulation Of Protein-containing Complex Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphoserine Residue Binding Positive Regulation Of Cell-cell Adhesion SH2 Domain Binding Positive Regulation Of T Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Insulin Receptor Binding Regulation Of T Cell Activation Negative Regulation Of Immune Response Regulation Of Cell-substrate Adhesion	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Cellular Developmental Process Regulation Of Cell Activation Intracellular Signaling Cassette Activation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Cell Differentiation Protein Phosphorylation Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Adhesion Regulation Of Immune Response Phosphorylation Leukocyte Activation Protein Kinase Activity Regulation Of T Cell Activation Lymphocyte Activation Regulation Of Programmed Cell Death Developmental Process Positive Regulation Of Protein Phosphorylation Nucleotide Binding Regulation Of Apoptotic Process
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