RNF4 and PARP1

Number of citations of the paper that reports this interaction (PubMedID 35013556)
54

Data Source:
BioGRID (enzymatic study)

		RNF4	PARP1
Description		ring finger protein 4	poly(ADP-ribose) polymerase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Nuclear Replication Fork Site Of DNA Damage
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Chromatin Binding Damaged DNA Binding RNA Binding Catalytic Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Enzyme Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Nucleosome Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding NAD Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Transcription Regulator Activator Activity NAD+-protein-serine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Immune System Process DNA Repair Double-strand Break Repair Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Carbohydrate Biosynthetic Process Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Mitochondrial DNA Repair Innate Immune Response Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Necroptotic Process Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Localization To Chromatin Cellular Response To Zinc Ion Cellular Response To Transforming Growth Factor Beta Stimulus Replication Fork Reversal DNA Repair-dependent Chromatin Remodeling Negative Regulation Of CGAS/STING Signaling Pathway Transcription Pausing By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleus Cellular Response To Oxygen-containing Compound Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Aldosterone Negative Regulation Of Adipose Tissue Development Positive Regulation Of Adipose Tissue Development Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Regulation Of Base-excision Repair Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Nerve Growth Factor Stimulus Protein Localization To Site Of Double-strand Break ATP Generation From Poly-ADP-D-ribose Negative Regulation Of ATP Biosynthetic Process
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Coronary artery disease ( 29212778) Leukocyte telomere length ( 31171785 32109421) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 30429480 32341527) Platelet count ( 29403010) Telomere length ( 29151059)
Interacting Genes		141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	123 interacting genes: AATF ANXA1 APTX ATM ATR BCL2 BGLT3 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CEBPA CENPA CENPB CTCF CTSB CTSG DTX2 DUX4 E2F1 E4F1 EPB41L2 ERBB2 ERCC6 ERG ETS1 FNDC3B FOXO1 GTF2F1 GZMB GZMM H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-4 H4C3 HDAC1 HDAC3 HECTD3 HIPK2 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LINC00624 LZTR1 MACROH2A1 MALAT1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 NUDT16 OGT OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF10 RNF144A RNF168 RNF4 RPS3A RSPH1 RXRA SENP1 SENP3 SMURF2 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 TP53BP1 TRIP12 UBE2I USP1 USP15 USP7 WEE2-AS1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		6047	142
HPRD ID		04167	01435
Ensembl ID		ENSG00000063978	ENSG00000143799
Uniprot IDs		P78317	P09874
PDB IDs		2EA6 2XEU 4PPE	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6M3I 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW 7AAA 7AAB 7AAC 7AAD 7CMW 7KK2 7KK3 7KK4 7KK5 7KK6 7ONR 7ONS 7ONT 7S68 7S6H 7S6M 7S81 7SCY 7SCZ 8FYY 8FYZ 8FZ1 8G0H 8HE7 8HLR 8JNZ 8U4W 9BPY 9CKC 9DMC 9ETQ 9ETR
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding	Nucleoplasm Nucleus DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Chromatin Organization Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Chromosome Protein Modification Process Negative Regulation Of DNA Metabolic Process DNA Repair DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Chromatin Cellular Response To Stress Post-translational Protein Modification Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Negative Regulation Of Cell Cycle Protein Localization To Chromosome Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Process Transcription Regulator Complex
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