RNF4 and SRPK2

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		RNF4	SRPK2
Gene Name		ring finger protein 4	SRSF protein kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Ligase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding
	Biological Process	Transcription, DNA-templated Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088)
Protein-Protein Interactions		37 interactors: AR ATXN1 ESR1 GSC2 HIST2H3C HMGA1 HNF4A IKBKG MECP2 PATZ1 PGR PML SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TRAIP TRIM28 TRPS1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2T UBE2W UEVLD	177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9
Entrez ID		6047	6733
HPRD ID		04167	04280
Ensembl ID		ENSG00000063978	ENSG00000135250
Uniprot IDs		P78317	P78362
PDB IDs		2EA6 2XEU	2X7G
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Transcription Initiation From RNA Polymerase II Promoter Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Modification-dependent Protein Catabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Aromatic Compound Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway ISG15-protein Conjugation	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?		barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Difference) ?		barrier begins calculations catalyzed conjugating d117 deprotonation dimeric e3 elusive employing gets guiding kcal ligase ligases md mechanics nucleophilic oxyanion qm ring sumo2 thioester transfer ub ubch5a ubiquitylation universal	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Intersection) ?