RNF4 and AIM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF4	AIM2
Description		ring finger protein 4	absent in melanoma 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Site Of Double-strand Break Canonical Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Double-stranded DNA Binding Protein Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Immune System Process Inflammatory Response Immune Response DNA Damage Response Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta T Cell Homeostasis Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Maturation Defense Response To Virus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Cellular Homeostasis Pyroptotic Inflammatory Response Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus AIM2 Inflammasome Complex Assembly Pyroptotic Cell Death Pyroptosome Complex Assembly
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Cytosolic sensors of pathogen-associated DNA The AIM2 inflammasome The AIM2 inflammasome
Drugs
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Neutrophil count in HIV-infection ( 25884002) Obesity-related traits ( 23251661) Psoriasis ( 25854761)
Interacting Genes		141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	4 interacting genes: ANP32B APPBP2 RNF4 SQSTM1
Entrez ID		6047	9447
HPRD ID		04167	05202
Ensembl ID		ENSG00000063978	ENSG00000163568
Uniprot IDs		P78317	O14862
PDB IDs		2EA6 2XEU 4PPE	3RN2 3RN5 3VD8 4O7Q 6MB2 7K3R
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding	Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination PML Body Post-translational Protein Modification Brown Fat Cell Proliferation Amphisome Regulation Of Protein Localization Regulation Of Kinetochore Assembly Macromolecule Catabolic Process Regulation Of Centromere Complex Assembly SUMO Polymer Binding Negative Regulation Of Protein Localization To Chromatin Microtubule End Proteolysis Lewy Body Response To Mitochondrial Depolarisation Protein Polyubiquitination Intracellular Membraneless Organelle Fat Cell Proliferation Protein Localization To Perinuclear Region Of Cytoplasm Regulation Of Protein Localization To Chromatin Ubiquitin-modified Protein Reader Activity Nucleoplasm Autolysosome Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Aggrephagy Negative Regulation Of Ferroptosis Protein Targeting To Vacuole Involved In Autophagy Regulation Of Ferroptosis Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Complex Stability Positive Regulation Of Protein Localization Molecular Sequestering Activity Pexophagy Proteasomal Protein Catabolic Process Inclusion Body Cul2-RING Ubiquitin Ligase Complex RNA Polymerase Binding Positive Regulation Of Protein Export From Nucleus Ventricular System Development Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Long-term Synaptic Potentiation Intracellular Protein Transport
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