RNF4 and HNRNPK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF4	HNRNPK
Description		ring finger protein 4	heterogeneous nuclear ribonucleoprotein K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Chromatin Podosome Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Cadherin Binding
	Biological Process	DNA Damage Response Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly Negative Regulation Of Protein Localization To Chromatin	MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Processing MRNA Processing Signal Transduction RNA Splicing Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Heterochromatin Formation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Random Inactivation Of X Chromosome Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Low-density Lipoprotein Particle Clearance
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		141 interacting genes: AIM2 AKAP17A AR ARID3C ARK2N ATF2 ATXN1 BCL2L1 BIRC6 BLM BTBD1 BTBD3 C14orf119 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK ID1 IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PARP1 PATZ1 PCBP3 PGR PHC1 PRMT5 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8 RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UCHL1 UCHL5 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	226 interacting genes: - ABI1 ABI2 ADRB2 ANKRD28 APBB1 APOBEC1 APOBEC3C AQP5 AURKA BCL2L13 CALCOCO2 CBLB CCAR1 CCDC187 CCDC33 CDKN1A CEBPA CEBPB CIRBP CMTM5 CNNM3 CRBN CSK CTNNBL1 DALRD3 DDX1 DDX17 DDX5 DHX9 DIDO1 DOCK2 DSCR9 DUX4 EIF3F ELAVL1 ETNK2 FBXL18 FBXO4 FBXO7 FBXW7 FNDC3B FOXD4L1 FOXD4L3 FOXP1 FYN GFI1B GRAP2 GRB2 GZMA GZMK HBZ HCK HMGB1 HNRNPA0 HNRNPL HNRNPLL IRGC ITK ITSN1 ITSN2 KCTD8 KHDRBS1 KHDRBS2 KHDRBS3 KLF1 LINC03040 LYN MAP2K2 MAPK10 MARCHF8 MARK4 MATR3 MDM2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MISP MRPL9 MYPOP NCK2 NEDD4 NOTO NPDC1 OGT PABPC1 PCBP1 PCBP2 PCDHB14 PCGF3 PELI2 PEX39 PGAP6 PIN1 PPP1R10 PRKCD PRMT1 PRPF31 PRPF40A QKI RALY RAMAC RASAL3 RASD1 RBFOX2 RBM10 RBM4 RBM41 RBM42 RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RNA18SN5 RNA28SN5 RNF26 RNF4 RPH3AL RTP5 SAFB SF1 SHANK3 SMAD3 SORBS3 SPG7 SRC SREK1 SRPK2 SRRT SRSF3 SUMO1 SUMO2 SYNCRIP TBP TCERG1 TCF23 TERF2IP TH TLE5 TYK2 U2AF1 UBE2I VAV1 WBP4 WWOX YBX1 YTHDC1 ZFC3H1 ZNF385C ZNF408 ZNF526 ZNF575 ZNF688 ZNF792 ZNRF2P1
Entrez ID		6047	3190
HPRD ID		04167	02834
Ensembl ID		ENSG00000063978	ENSG00000165119
Uniprot IDs		P78317	B4DUQ1 P61978
PDB IDs		2EA6 2XEU 4PPE	1J5K 1KHM 1ZZI 1ZZJ 1ZZK 7CRE 7CRU 7RJK 7RJO
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Ubiquitin-protein Transferase Activity Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process DNA Binding Chromatin Regulation Of Transcription By RNA Polymerase II Keratinization Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Monoubiquitination Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein-containing Complex DNA Damage Response Positive Regulation Of Metabolic Process Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Nucleic Acid Metabolic Process Thioesterase Binding	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Translation Extracellular Vesicle Positive Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Angiogenesis Regulation Of RNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Vasculature Development MRNA Processing Negative Regulation Of Locomotion Positive Regulation Of Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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