RGS2 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RGS2	ARFGAP1
Description		regulator of G protein signaling 2	ARF GTPase activating protein 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction
Pathways		G alpha (q) signalling events	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX	39 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23
Entrez ID		5997	55738
HPRD ID		02917	06443
Ensembl ID		ENSG00000116741	ENSG00000101199
Uniprot IDs		P41220	Q53F62 Q8N6T3
PDB IDs		2AF0 2V4Z 4EKC 4EKD	3DWD 3O47
Enriched GO Terms of Interacting Partners?		Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity	Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance
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