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RGS2 and FZD5
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
RGS2
FZD5
Description
regulator of G protein signaling 2
frizzled class receptor 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Membrane
Golgi Membrane
Early Endosome
Golgi Apparatus
Plasma Membrane
Bicellular Tight Junction
Cell Surface
Membrane
Axon
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Cell Projection
Perikaryon
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
G-protein Alpha-subunit Binding
GTPase Activity
GTPase Activator Activity
Protein Binding
Calmodulin Binding
Adenylate Cyclase Inhibitor Activity
Beta-tubulin Binding
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
Lipid Binding
Wnt-protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Wnt Receptor Activity
Protein-containing Complex Binding
Biological Process
Response To Amphetamine
Regulation Of Translation
G Protein-coupled Receptor Signaling Pathway
Spermatogenesis
Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Neuron Projection Development
Negative Regulation Of Translation
Response To Ethanol
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of JNK Cascade
Brown Fat Cell Differentiation
Relaxation Of Cardiac Muscle
Relaxation Of Vascular Associated Smooth Muscle
Maternal Process Involved In Female Pregnancy
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway
Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Glycine Import Across Plasma Membrane
Embryonic Axis Specification
Angiogenesis
Eye Development
Vasculature Development
Glandular Epithelial Cell Maturation
Positive Regulation Of T Cell Cytokine Production
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Synapse Assembly
Negative Regulation Of Cell Population Proliferation
Anterior/posterior Axis Specification, Embryo
Wnt Signaling Pathway
Neuron Differentiation
Embryonic Camera-type Eye Development
Post-embryonic Camera-type Eye Development
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
Non-canonical Wnt Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Camera-type Eye Morphogenesis
System Development
Spemann Organizer Formation
Canonical Wnt Signaling Pathway
Apoptotic Process Involved In Morphogenesis
Intestinal Epithelial Cell Maturation
Branching Involved In Labyrinthine Layer Morphogenesis
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Labyrinthine Layer Blood Vessel Development
Chorionic Trophoblast Cell Differentiation
Cellular Response To Molecule Of Bacterial Origin
Regulation Of Chorionic Trophoblast Cell Proliferation
Regulation Of Mitophagy
Positive Regulation Of Protein Targeting To Mitochondrion
Regulation Of Bicellular Tight Junction Assembly
Pathways
G alpha (q) signalling events
Class B/2 (Secretin family receptors)
Ca2+ pathway
Ca2+ pathway
Asymmetric localization of PCP proteins
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Signaling by RNF43 mutants
Drugs
Diseases
GWAS
Coronary artery calcification (
23870195
)
Response to quetiapine in schizophrenia (
29503163
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Interacting Genes
61 interacting genes:
ADCY5
ADRA1A
ADRB2
ARFGAP1
BBS10
CALM1
CEP126
CHD3
CIAO1
CLTA
COMT
COPB1
COPB2
CRMP1
CTSB
DDR1
DUSP21
DYNLL1
EGFR
EIF3L
FZD5
GDE1
GIT1
GNA15
GNAI3
GNAQ
GNAS
HAUS5
HSPA8
IER3IP1
KLK8
LIG1
LRFN1
MARCHF6
METTL18
MON1A
MTUS2
NINL
NIPSNAP1
PPP1R9B
PRKCA
PRKCB
PRKCG
PRKCSH
PRKG1
PRKN
RAB2A
RABAC1
RAP1B
REEP5
RIN3
SCN5A
TSPAN15
TUBB2B
UBC
VPS29
WDR74
XRCC6
ZBTB48
ZNF579
ZYX
13 interacting genes:
ABI3BP
GOPC
GSK3B
LRP6
LZTFL1
RGS2
ROR2
RPS6KA6
SLC22A2
SLC35B1
UBTD1
WNT5A
WNT7A
Entrez ID
5997
7855
HPRD ID
02917
03427
Ensembl ID
ENSG00000116741
ENSG00000163251
Uniprot IDs
P41220
Q13467
PDB IDs
2AF0
2V4Z
4EKC
4EKD
5URY
5URZ
6O39
6WW2
Enriched GO Terms of Interacting Partners
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Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Guanyl Nucleotide Binding
Calyx Of Held
G-protein Beta/gamma-subunit Complex Binding
Cognition
Nucleotide Binding
Regulation Of Secretion By Cell
Scaffold Protein Binding
Protein-containing Complex Binding
Learning Or Memory
Heterotrimeric G-protein Complex
G Protein-coupled Receptor Binding
Regulation Of Transport
Response To Ketone
Regulation Of Secretion
Enzyme Binding
Histone H3T6 Kinase Activity
Regulation Of Neurotransmitter Secretion
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Response To Corticosterone
Diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Synaptic Vesicle Exocytosis
Regulation Of Insulin Secretion
Regulation Of Muscle System Process
Regulation Of Muscle Contraction
Response To Alcohol
Regulation Of Protein Secretion
System Process
Response To Catecholamine
Cytoplasm
Nervous System Process
Adrenergic Receptor Signaling Pathway
Modulation Of Chemical Synaptic Transmission
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Regulation Of Exocytosis
Response To Hormone
Cellular Localization
Protein Kinase C Signaling
Membrane
Regulation Of Peptide Hormone Secretion
Establishment Of Localization In Cell
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Regulation Of Cellular Component Organization
G Protein-coupled Receptor Signaling Pathway
Centrosome
Regulation Of Establishment Of Protein Localization
Response To Psychosocial Stress
Adenylate Cyclase Activator Activity
Intracellular Protein Localization
G Protein Activity
Canonical Wnt Signaling Pathway
Postsynapse Assembly
Wnt Signaling Pathway
Frizzled Binding
Positive Regulation Of Protein Localization To Synapse
Toxin Transmembrane Transporter Activity
Regulation Of Neuron Projection Development
Wnt Signalosome
Regulation Of Protein Localization To Cilium
Epithelial To Mesenchymal Transition
Midbrain Dopaminergic Neuron Differentiation
Excitatory Synapse Assembly
Secondary Palate Development
Presynapse Assembly
Establishment Of Cell Polarity
Negative Regulation Of Developmental Process
Mesenchymal Cell Differentiation
Presynapse Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of MAPK Cascade
Regulation Of Cell Projection Organization
Uterus Development
Positive Regulation Of Cell Projection Organization
Central Nervous System Neuron Differentiation
Regulation Of Axonogenesis
Regulation Of JNK Cascade
Regulation Of Protein Localization To Synapse
Wnt-protein Binding
Positive Regulation Of Neuron Projection Development
Establishment Or Maintenance Of Cell Polarity
Embryonic Axis Specification
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Response To Lipid
Midbrain Development
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Dopaminergic Neuron Differentiation
Cellular Response To Lipid
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Epithelial Cell Proliferation
Neuron Projection Organization
Regulation Of Protein Localization
Postsynapse Organization
Presynapse
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Protein Localization
Regulation Of Microtubule Anchoring At Centrosome
Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway
Receptor Tyrosine Kinase-like Orphan Receptor Binding
Chemoattraction Of Serotonergic Neuron Axon
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