RGS2 and ADRA1A

Number of citations: 0 (PubMedID 15917235)
Data Source: HPRD (in vitro)

		RGS2	ADRA1A
Name		regulator of G protein signaling 2	adrenoceptor alpha 1A
Structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Caveola Membrane Nuclear Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane	MAPK Cascade Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Apoptotic Process Regulation Of Muscle Contraction Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Vasoconstriction Positive Regulation Of Synaptic Transmission, GABAergic Organ Growth Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Cardiac Muscle Contraction Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Pilomotor Reflex Neuron-glial Cell Signaling
Pathways		G alpha (q) signalling events	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		None	Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Promazine Prochlorperazine Dipivefrin Droperidol Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Amoxapine Lamotrigine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Nicergoline Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Dobutamine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergometrine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone Lofexidine R450 Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Silodosin Asenapine Ocaperidone Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Niguldipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Propiverine Tiapride Dihydroergocristine Aripiprazole lauroxil
GWAS		Coronary artery calcification ( 23870195 ) Response to quetiapine in schizophrenia ( 29503163 )	Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Response to amphetamines ( 22952603 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 )
Novel Interactors		1 novel interactors: SUN2	None recorded
Interacting Genes		61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX	30 interacting genes: ABR ADGRA3 ADRA1B ADRA1D ANO8 ATP6AP2 BMP1 CD81 CXCR1 CXCR2 FAM241B FAM50B FLNC GDE1 GPR37 HHATL KIAA2013 KLHL22 MBOAT7 NOS1 NTNG2 PPP1R9B RGS2 SCN1B SGCB TBC1D20 TMEM234 TPCN2 UBR4 UGT8
Entrez ID		5997	148
HPRD ID		02917	00081
Ensembl ID		ENSG00000116741	ENSG00000120907
Uniprot IDs		P41220	B0ZBD3 P35348
PDB IDs		2AF0 2V4Z 4EKC 4EKD	7YM8 7YMH 7YMJ 8HN1 8THK 8THL
GO Terms Enriched among Interactors		Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity	Membrane Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Alpha1-adrenergic Receptor Activity Calcium-mediated Signaling Interleukin-8 Binding Neuron-glial Cell Signaling G Protein-coupled Receptor Activity Regulation Of Blood Circulation C-X-C Chemokine Receptor Activity Adrenergic Receptor Activity Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor-mediated Endocytosis Dendritic Spine Membrane Receptor Internalization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Cardiac Muscle Contraction Dendritic Cell Chemotaxis Positive Regulation Of Sodium Ion Transmembrane Transport Intracellular Signaling Cassette Adrenergic Receptor Signaling Pathway Regulation Of Striated Muscle Contraction Intercellular Bridge Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Immobilization Stress Dendritic Cell Migration Regulation Of MAPK Cascade Sarcolemma Muscle System Process Myoblast Fusion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Macrophage Fusion Cell-cell Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Syncytium Formation By Plasma Membrane Fusion Transmembrane Transporter Binding Sodium Channel Regulator Activity Regulation Of Membrane Repolarization Positive Regulation Of Sodium Ion Transport Response To Amphetamine Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Corticospinal Neuron Axon Guidance N-acylsphingosine Galactosyltransferase Activity