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RGS2 and WDR74
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
RGS2
WDR74
Gene Name
regulator of G-protein signaling 2
WD repeat domain 74
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Neuron Projection
Nucleus
Nucleolus
Molecular Function
GTPase Activator Activity
Protein Binding
Calmodulin Binding
Beta-tubulin Binding
Molecular_function
Biological Process
Regulation Of Translation
Cell Cycle
Spermatogenesis
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Negative Regulation Of Phospholipase Activity
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Microtubule Polymerization
Termination Of G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Negative Regulation Of CAMP-mediated Signaling
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Brown Fat Cell Differentiation
Relaxation Of Cardiac Muscle
Relaxation Of Vascular Smooth Muscle
Positive Regulation Of Cardiac Muscle Contraction
Regulation Of Adrenergic Receptor Signaling Pathway
Blastocyst Formation
Biological_process
RNA Metabolic Process
Pathways
G alpha (q) signalling events
G alpha (q) signalling events
Signaling by GPCR
GPCR downstream signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions
58 interactors:
ADCY5
ADRA1A
ADRB2
ARFGAP1
BBS10
CALM1
CHD3
CLTA
COMT
COPB1
COPB2
CRMP1
CTSB
DDR1
DUSP21
DYNLL1
EIF3L
FZD5
GDE1
GIT1
GNA15
GNAI3
GNAQ
GNAS
HAUS5
HSPA8
IER3IP1
KIAA1377
KLK8
LIG1
LRFN1
METTL18
MON1A
MTUS2
NINL
NIPSNAP1
PARK2
PPP1R9B
PRKCA
PRKCB
PRKCG
PRKCSH
PRKG1
RAB2A
RABAC1
RAP1B
REEP5
RIN3
SCN5A
TSPAN15
TUBB2B
UBC
VPS29
WDR74
XRCC6
ZBTB48
ZNF579
ZYX
3 interactors:
NUDT3
RCHY1
RGS2
Entrez ID
5997
54663
HPRD ID
02917
08548
Ensembl ID
ENSG00000116741
ENSG00000133316
Uniprot IDs
P41220
Q6RFH5
PDB IDs
2AF0
2V4Z
4EKC
4EKD
Enriched GO Terms of Interacting Partners
?
Activation Of Phospholipase C Activity
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phospholipase Activity
Platelet Activation
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Regulation Of Catalytic Activity
Regulation Of Body Fluid Levels
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Response To Wounding
Blood Coagulation
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Hemostasis
Wound Healing
Cell-cell Signaling
Regulation Of Phosphorus Metabolic Process
Regulation Of Adenylate Cyclase Activity
Nervous System Development
Regulation Of Cyclase Activity
Activation Of Adenylate Cyclase Activity
Signaling
Response To Stress
Neurotrophin Signaling Pathway
Cell Communication
Regulation Of Phosphorylation
Dopamine Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Developmental Process
Positive Regulation Of Adenylate Cyclase Activity
Regulation Of Kinase Activity
Response To Organic Substance
Cellular Response To Stimulus
Regulation Of Muscle Contraction
Anatomical Structure Development
Regulation Of CAMP Biosynthetic Process
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
COPI-coated Vesicle Budding
COPI Coating Of Golgi Vesicle
Positive Regulation Of Hydrolase Activity
Cell Activation
Membrane Organization
Regulation Of CAMP Metabolic Process
Regulation Of Protein Phosphorylation
System Development
Positive Regulation Of Lyase Activity
Enzyme Linked Receptor Protein Signaling Pathway
Golgi Vesicle Budding
Adrenergic Receptor Signaling Pathway
Diphosphoinositol Polyphosphate Catabolic Process
Diadenosine Polyphosphate Catabolic Process
Regulation Of Adrenergic Receptor Signaling Pathway
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of CAMP-mediated Signaling
Negative Regulation Of Phospholipase Activity
Relaxation Of Vascular Smooth Muscle
Negative Regulation Of Cardiac Muscle Hypertrophy
Relaxation Of Smooth Muscle
Negative Regulation Of Muscle Hypertrophy
Positive Regulation Of Striated Muscle Contraction
Positive Regulation Of Microtubule Polymerization
Relaxation Of Cardiac Muscle
Negative Regulation Of Smooth Muscle Contraction
Negative Regulation Of Lipase Activity
Negative Regulation Of Muscle Contraction
Regulation Of CAMP-mediated Signaling
Relaxation Of Muscle
Positive Regulation Of Heart Contraction
Regulation Of Microtubule Polymerization
Regulation Of Cardiac Muscle Hypertrophy
Vasodilation
Brown Fat Cell Differentiation
Protein Autoubiquitination
Inositol Phosphate Metabolic Process
Alcohol Catabolic Process
Regulation Of Smooth Muscle Contraction
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Termination Of G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Termination Of Signal Transduction
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Microtubule Polymerization Or Depolymerization
Regulation Of Blood Vessel Size
Regulation Of Tube Size
Regulation Of Cardiac Muscle Contraction
Nucleotide Catabolic Process
Negative Regulation Of MAP Kinase Activity
Regulation Of Phospholipase Activity
Regulation Of Striated Muscle Contraction
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud
?
3t3
adipocyte
already
arrested
beginning
cloned
clones
differentially
earliest
ebpalpha
hif
hsp105
inducers
l1
master
mrnas
nih
nineteen
place
ppargamma2
preadipocyte
proliferating
regulators
rho
seemed
steps
takes
tc10
vdr
Tagcloud (Difference)
?
3t3
adipocyte
already
arrested
beginning
cloned
clones
differentially
earliest
ebpalpha
hif
hsp105
inducers
l1
master
mrnas
nih
nineteen
place
ppargamma2
preadipocyte
proliferating
regulators
rho
seemed
steps
takes
tc10
vdr
Tagcloud (Intersection)
?