RBP1 and LRP2

Number of citations of the paper that reports this interaction (PMID 10203351)
21

Data Source:
HPRD (in vitro)

		RBP1	LRP2
Gene Name		retinol binding protein 1, cellular	low density lipoprotein receptor-related protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Retinoid Binding Retinal Binding Retinol Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Retinoid Metabolic Process Vitamin A Metabolic Process Transport Phototransduction, Visible Light	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways		Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Diseases associated with visual transduction Retinoid metabolism and transport	Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Vitamin A Acitretin	Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS			Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		14 interactors: BRMS1 BRMS1L HDAC1 HDAC2 IKBKG ING1 LINC00152 LRAT LRP2 MED26 RBBP4 RBBP7 SAP30 SIN3A	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		5947	4036
HPRD ID		07036	02509
Ensembl ID		ENSG00000114115	ENSG00000081479
Uniprot IDs		P09455	P98164 Q7Z5C0 Q7Z5C1
PDB IDs			2M0P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization Histone Deacetylation Protein Deacetylation Chromatin Modification Chromosome Organization Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated RNA Biosynthetic Process ATP-dependent Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Histone Modification Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Remodeling Organelle Organization Fungiform Papilla Formation Fungiform Papilla Morphogenesis Nucleobase-containing Compound Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Heterocycle Metabolic Process Eyelid Development In Camera-type Eye Cellular Aromatic Compound Metabolic Process Hair Follicle Placode Formation Cellular Nitrogen Compound Metabolic Process Tongue Morphogenesis Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Histone H4 Deacetylation Nitrogen Compound Metabolic Process Regulation Of Cell Death CENP-A Containing Nucleosome Assembly Histone H3 Deacetylation Regulation Of Metabolic Process	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hdac9 hoxa11 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?