ZBP1 and TRIP6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ZBP1	TRIP6
Gene Name		Z-DNA binding protein 1	thyroid hormone receptor interactor 6
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Biological_process Metabolic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways		Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN RIP-mediated NFkB activation via ZBP1 Innate Immune System
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		8 interactors: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		81030	7205
HPRD ID		09484	04242
Ensembl ID		ENSG00000124256	ENSG00000087077
Uniprot IDs		Q9H171	F2ZC06 Q15654
PDB IDs		2L4M 2LNB 3EYI 4KA4	1X61 2DLO
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Fat Cell Differentiation Viral Life Cycle Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Chromatin Binding	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?