ZBP1 and TRAF3

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		ZBP1	TRAF3
Gene Name		Z-DNA binding protein 1	TNF receptor-associated factor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Biological_process Metabolic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus
Pathways		Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN RIP-mediated NFkB activation via ZBP1 Innate Immune System	Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075)	Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		8 interactors: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11
Entrez ID		81030	7187
HPRD ID		09484	03539
Ensembl ID		ENSG00000124256	ENSG00000131323
Uniprot IDs		Q9H171	A6NHG8 Q13114
PDB IDs		2L4M 2LNB 3EYI 4KA4	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Fat Cell Differentiation Viral Life Cycle Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Chromatin Binding	Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death
Tagcloud ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Difference) ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Intersection) ?