ZBP1 and PLXDC2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ZBP1	PLXDC2
Gene Name		Z-DNA binding protein 1	plexin domain containing 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding	Receptor Activity Protein Binding
	Biological Process	Biological_process Metabolic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway	Multicellular Organismal Development
Pathways		Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN RIP-mediated NFkB activation via ZBP1 Innate Immune System
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075)	Diabetic retinopathy ( 21310492)
Protein-Protein Interactions		8 interactors: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	1 interactors: ZBP1
Entrez ID		81030	84898
HPRD ID		09484	08440
Ensembl ID		ENSG00000124256	ENSG00000120594
Uniprot IDs		Q9H171	Q6UX71
PDB IDs		2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?		White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Fat Cell Differentiation Viral Life Cycle Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Chromatin Binding	Regulation Of MRNA Stability Involved In Response To Stress CRD-mediated MRNA Stabilization Positive Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Stabilization Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Type I Interferon Production Negative Regulation Of Translation Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Cytokine Biosynthetic Process MRNA Transport RNA Transport RNA Localization Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Translation Positive Regulation Of Cytokine Production
Tagcloud ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	3kda centrifugal ddr1 detailing ectodomains fgfbp1 gaining gpa33 identifications intramembrane ionscore lim1215 lim1863 macc1 mascot merops mspro nanolc percolator rip salient sanger secretome secretopeptidome smagp thresholding tumourigenesis ultrafiltration utilised
Tagcloud (Difference) ?		concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped	3kda centrifugal ddr1 detailing ectodomains fgfbp1 gaining gpa33 identifications intramembrane ionscore lim1215 lim1863 macc1 mascot merops mspro nanolc percolator rip salient sanger secretome secretopeptidome smagp thresholding tumourigenesis ultrafiltration utilised
Tagcloud (Intersection) ?