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SENP2 and SYNE4
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SENP2
SYNE4
Description
SUMO specific peptidase 2
spectrin repeat containing nuclear envelope family member 4
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Nuclear Body
PML Body
Nuclear Membrane
Nucleus
Nuclear Envelope
Nuclear Outer Membrane
Membrane
Meiotic Nuclear Membrane Microtubule Tethering Complex
Molecular Function
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
DeSUMOylase Activity
SUMO-specific Endopeptidase Activity
Protein Binding
Biological Process
Proteolysis
Heart Development
Protein Transport
Wnt Signaling Pathway
Protein Sumoylation
Protein Desumoylation
Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of DNA Endoreduplication
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Transport
Regulation Of Macromolecule Metabolic Process
Trophoblast Giant Cell Differentiation
Labyrinthine Layer Development
Regulation Of Primary Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Establishment Of Epithelial Cell Apical/basal Polarity
Pathways
SUMO is proteolytically processed
Drugs
Diseases
GWAS
Diastolic blood pressure (
27841878
28135244
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31015462
31152163
)
Height (
28552196
)
Hip circumference (
28552196
)
JT interval (
29874175
)
PR interval (
30046033
32439900
)
QRS duration (
30012220
)
Seborrheic dermatitis (
29203360
)
Systolic blood pressure (
26969751
27841878
)
Interacting Genes
40 interacting genes:
ACSF2
AGTRAP
APOC2
APOC4
APP
AR
ARL6IP1
ARMC12
AXIN1
CDCA5
CDK5RAP2
DAXX
ERCC6
FUNDC1
FZR1
HCCS
IKBKG
KASH5
KPNA1
KPNB1
LMNA
MYC
NACC1
NEDD4L
NUP153
OGT
PML
RANGAP1
RETREG3
RPRM
SDR16C5
STK38
SUMO1
SUMO2
SUMO3
SYNE4
TMEM239
TNFRSF10D
TPD52
TRIM63
56 interacting genes:
ABT1
ADIPOQ
BRICD5
C3orf52
CD47
CEP19
CFTR
CLDN19
CLDN7
CLDN8
CLEC7A
CMTM5
CSNK2B
CXCL9
DEFB121
ECE2
EDDM3B
EMP1
ENTPD3
FAM241B
FATE1
GADD45A
GSK3B
IGFBP5
ITM2B
KLHL12
KLRG1
KTN1
MALL
MARCHF2
NAGK
OCLN
OLFM4
OSTCP1
PAQR5
PLPP6
RIPPLY2
RPS6KA6
SEC22A
SEC23B
SENP2
SFTPC
SLN
SMCO4
TCEA2
TMEM115
TMEM140
TMEM147
TMEM182
TMEM248
TMPRSS4
TRIM69
TSPAN15
VTI1B
ZNF250
ZNF648
Entrez ID
59343
163183
HPRD ID
07002
08776
Ensembl ID
ENSG00000163904
ENSG00000181392
Uniprot IDs
Q9HC62
Q8N205
PDB IDs
1TGZ
1TH0
2IO0
2IO1
2IO2
2IO3
3ZO5
5AEK
6R16
6WMD
Enriched GO Terms of Interacting Partners
?
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Protein Sumoylation
Positive Regulation Of Proteolysis
Ubiquitin Protein Ligase Binding
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Pore
Regulation Of Proteolysis
Nuclear Membrane
Protein Modification By Small Protein Conjugation
Protein Localization To Nucleus
PML Body
Protein Tag Activity
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Protein Import Into Nucleus
Nuclear Envelope
Import Into Nucleus
Very-low-density Lipoprotein Particle
Chromatin Organization
Post-translational Protein Modification
Endoplasmic Reticulum Tubular Network
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Nuclear Localization Sequence Binding
High-density Lipoprotein Particle
Regulation Of Protein Catabolic Process
Ubiquitin-like Protein Ligase Binding
Positive Regulation Of Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate-density Lipoprotein Particle
Nucleus Organization
Protein Binding
DNA Damage Response
Positive Regulation Of Protein Metabolic Process
Protein Localization To Organelle
Regulation Of Proteasomal Protein Catabolic Process
PML Body Organization
Chromatin Remodeling
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Metabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Apoptotic Process
Regulation Of Protein Localization
Molecular Condensate Scaffold Activity
Programmed Cell Death
Protein Modification Process
NLS-dependent Protein Nuclear Import Complex
Meiotic Nuclear Membrane Microtubule Tethering Complex
Protein Binding
Bicellular Tight Junction Assembly
Tight Junction Organization
Tight Junction Assembly
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Apicolateral Plasma Membrane
Regulation Of Glycogen (starch) Synthase Activity
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Tagcloud (Intersection)
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