SENP2 and RANGAP1

Number of citations of the paper that reports this interaction (PubMedID 25412743)
22

Data Source:
BioGRID (enzymatic study)

		SENP2	RANGAP1
Description		SUMO specific peptidase 2	Ran GTPase activating protein 1
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body PML Body Nuclear Membrane	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Aggresome Dendrite Nuclear Membrane Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle SUMO Ligase Complex Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Proteolysis Heart Development Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of DNA Endoreduplication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Regulation Of Macromolecule Metabolic Process Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Signal Transduction Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Nuclear Export Cellular Response To Peptide Hormone Stimulus Activation Of GTPase Activity Cellular Response To Vasopressin
Pathways		SUMO is proteolytically processed	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SUMOylation of nuclear envelope proteins
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878 28135244) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462 31152163) Height ( 28552196) Hip circumference ( 28552196) JT interval ( 29874175) PR interval ( 30046033 32439900) QRS duration ( 30012220) Seborrheic dermatitis ( 29203360) Systolic blood pressure ( 26969751 27841878)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		40 interacting genes: ACSF2 AGTRAP APOC2 APOC4 APP AR ARL6IP1 ARMC12 AXIN1 CDCA5 CDK5RAP2 DAXX ERCC6 FUNDC1 FZR1 HCCS IKBKG KASH5 KPNA1 KPNB1 LMNA MYC NACC1 NEDD4L NUP153 OGT PML RANGAP1 RETREG3 RPRM SDR16C5 STK38 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TNFRSF10D TPD52 TRIM63	23 interacting genes: AXIN2 CCL5 CDK1 CDK2 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MUL1 OGT PDGFRL PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1
Entrez ID		59343	5905
HPRD ID		07002	03839
Ensembl ID		ENSG00000163904	ENSG00000100401
Uniprot IDs		Q9HC62	P46060 Q9BSK3
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3 3ZO5 5AEK	1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M 9B62
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Ubiquitin Protein Ligase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore Regulation Of Proteolysis Nuclear Membrane Protein Modification By Small Protein Conjugation Protein Localization To Nucleus PML Body Protein Tag Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Import Into Nucleus Nuclear Envelope Import Into Nucleus Very-low-density Lipoprotein Particle Chromatin Organization Post-translational Protein Modification Endoplasmic Reticulum Tubular Network Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nuclear Localization Sequence Binding High-density Lipoprotein Particle Regulation Of Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate-density Lipoprotein Particle Nucleus Organization Protein Binding DNA Damage Response Positive Regulation Of Protein Metabolic Process Protein Localization To Organelle Regulation Of Proteasomal Protein Catabolic Process PML Body Organization Chromatin Remodeling Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Regulation Of Protein Localization Molecular Condensate Scaffold Activity Programmed Cell Death Protein Modification Process NLS-dependent Protein Nuclear Import Complex Meiotic Nuclear Membrane Microtubule Tethering Complex	Protein Sumoylation Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Proteolysis SUMO Transferase Activity Regulation Of Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol DeSUMOylase Activity Nuclear Pore Protein Desumoylation Nucleoplasm Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Catabolic Process Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Tag Activity Protein Localization To Organelle Cyclin-dependent Protein Kinase Activity Ubiquitin-like Protein Ligase Binding Positive Regulation Of Proteolysis Magnesium Ion Binding SUMO Ligase Complex Nuclear Envelope Positive Regulation Of Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding SUMO-specific Endopeptidase Activity Protein Modification By Small Protein Removal Nuclear Transport Nucleocytoplasmic Transport Regulation Of Protein Localization Regulation Of Protein Transport Histone Kinase Activity Nuclear Export Cytosol Regulation Of Cell Junction Assembly Negative Regulation Of Metabolic Process Regulation Of Intracellular Transport Cell Division Signal Transduction
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