SENP2 and TPD52

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SENP2	TPD52
Gene Name		SUMO1/sentrin/SMT3 specific peptidase 2	tumor protein D52
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm PML Body Cytoplasmic Vesicle Nuclear Membrane	Cytoplasm Endoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding SUMO-specific Protease Activity Protein Domain Specific Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Proteolysis Heart Development Dorsal/ventral Axis Specification Protein Transport Wnt Signaling Pathway Protein Sumoylation Protein Desumoylation Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Binding Regulation Of DNA Endoreduplication Negative Regulation Of Chromatin Binding Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Development Spongiotrophoblast Layer Development Regulation Of G1/S Transition Of Mitotic Cell Cycle	Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis B Cell Differentiation Secretion
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation Processing and activation of SUMO	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		21 interactors: AGTRAP APP ARL6IP1 AXIN1 CCDC155 CDCA5 CDK5RAP2 DAXX FUNDC1 IKBKG NEDD4L NUP153 PML RANGAP1 SUMO1 SUMO2 SUMO3 SYNE4 TMEM239 TPD52 TRIM63	8 interactors: ANXA6 MAL2 SENP2 SOCS2 SRPK2 TPD52L1 TPD52L2 TPD52L3
Entrez ID		59343	7163
HPRD ID		07002	04963
Ensembl ID			ENSG00000076554
Uniprot IDs		Q9HC62	P55327
PDB IDs		1TGZ 1TH0 2IO0 2IO1 2IO2 2IO3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Sumoylation Positive Regulation Of Cellular Protein Metabolic Process PML Body Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Metabolic Process Mitotic Cell Cycle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process JNK Cascade Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Cycle Viral Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Stress-activated MAPK Cascade Establishment Of Organelle Localization Stress-activated Protein Kinase Signaling Cascade Nucleus Organization Cell Cycle Process Regulation Of Cellular Localization Cellular Response To Stress Mitotic Cell Cycle Process Response To Abiotic Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Organelle Localization Protein Localization To Nucleus Regulation Of Protein Localization Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Intracellular Transport Cell Surface Receptor Signaling Pathway Organelle Organization Activation Of JUN Kinase Activity Cellular Response To Stimulus Cellular Response To DNA Damage Stimulus Establishment Of Chromosome Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply	adjuvant antigens autoimmunity broad burden class considers demonstrating efforts exhibiting expected focusing highlighting largest obstacle oncogenesis overcome overexpressed perhaps possibly preclinical preclude presumed promising shed subset tolerance understudied vaccine
Tagcloud (Difference) ?		adequate aerobic atp consistently displaying exhibit glucose glycolysis glycolytic hif1alpha knockout lactate ly294002 mcf7 mef mefs metabolism protease proteases represses rescued respiration reveals senps shifts subcellular sumo sumoylate supply	adjuvant antigens autoimmunity broad burden class considers demonstrating efforts exhibiting expected focusing highlighting largest obstacle oncogenesis overcome overexpressed perhaps possibly preclinical preclude presumed promising shed subset tolerance understudied vaccine
Tagcloud (Intersection) ?