TRPV4 and YES1

Number of citations of the paper that reports this interaction (PMID 12538589)
30

Data Source:
HPRD (in vivo, in vitro)

		TRPV4	YES1
Gene Name		transient receptor potential cation channel, subfamily V, member 4	YES proto-oncogene 1, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Integral Component Of Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Osmosensor Activity Protein Kinase C Binding Cation Channel Activity Calcium Channel Activity Calmodulin Binding ATP Binding Microtubule Binding Protein Kinase Binding SH2 Domain Binding Alpha-tubulin Binding Beta-tubulin Binding Actin Filament Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Cortical Microtubule Organization Microtubule Polymerization Regulation Of Response To Osmotic Stress Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs			Dasatinib
Diseases
GWAS			Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		14 interactors: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B
Entrez ID		59341	7525
HPRD ID		05667	01285
Ensembl ID		ENSG00000111199	ENSG00000176105
Uniprot IDs		Q9HBA0	P07947
PDB IDs		4DX1 4DX2	2HDA
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Protein Autophosphorylation Leukocyte Migration Innate Immune Response Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Vesicle-mediated Transport Membrane Tubulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Immune Response Response To Platelet-derived Growth Factor Regulation Of Vesicle-mediated Transport Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endocytosis Regulation Of Lymphocyte Activation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Peptide Hormone Regulation Of Defense Response To Virus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Response To Organonitrogen Compound Response To Peptide Immune Response Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Defense Response Ephrin Receptor Signaling Pathway Phagocytosis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Defense Response To Virus By Virus Viral Process Response To Hormone	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity
Tagcloud ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
Tagcloud (Difference) ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
Tagcloud (Intersection) ?