TRPV4 and OS9

Number of citations of the paper that reports this interaction (PMID 17932042)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		TRPV4	OS9
Gene Name		transient receptor potential cation channel, subfamily V, member 4	osteosarcoma amplified 9, endoplasmic reticulum lectin
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Integral Component Of Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Lumen Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Actin Binding Osmosensor Activity Protein Kinase C Binding Cation Channel Activity Calcium Channel Activity Calmodulin Binding ATP Binding Microtubule Binding Protein Kinase Binding SH2 Domain Binding Alpha-tubulin Binding Beta-tubulin Binding Actin Filament Binding	Glycoprotein Binding Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Cortical Microtubule Organization Microtubule Polymerization Regulation Of Response To Osmotic Stress Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response	Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	16 interactors: ACVR1B CPNE6 CREB3 DCSTAMP EGLN1 EGLN3 EIF6 FOXM1 HIF1A MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		59341	10956
HPRD ID		05667	17804
Ensembl ID		ENSG00000111199	ENSG00000135506
Uniprot IDs		Q9HBA0	B4E321 Q13438
PDB IDs		4DX1 4DX2	3AIH
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Protein Autophosphorylation Leukocyte Migration Innate Immune Response Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Vesicle-mediated Transport Membrane Tubulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Immune Response Response To Platelet-derived Growth Factor Regulation Of Vesicle-mediated Transport Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endocytosis Regulation Of Lymphocyte Activation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Peptide Hormone Regulation Of Defense Response To Virus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Response To Organonitrogen Compound Response To Peptide Immune Response Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Defense Response Ephrin Receptor Signaling Pathway Phagocytosis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Defense Response To Virus By Virus Viral Process Response To Hormone	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Oxygen Levels Cellular Response To Stress Oxygen Homeostasis Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Differentiation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Regulation Of Growth Nodal Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Erythrocyte Differentiation 4-hydroxyproline Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Activin Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-proline Hydroxylation Protein Hydroxylation Activin Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Myeloid Cell Differentiation Heterocycle Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus In Utero Embryonic Development Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Growth Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Cellular Macromolecular Complex Assembly Cellular Response To Stimulus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cortical Microtubule Organization Osmosensory Signaling Pathway Neural Fold Elevation Formation Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid	branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana
Tagcloud (Difference) ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid	branch c57y calnexin calreticulin cnx constrained erad folded folding futile glc1man7glcnac2 glycan glycans glycoproteins harbours improperly interconnected kifunensine lectins mannosidases mns4 mns5 oligosaccharide sel1l sort stabilized strubbelig subex thaliana
Tagcloud (Intersection) ?