TRPV4 and MAP7

Number of citations of the paper that reports this interaction (PMID 14517216)
14

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TRPV4	MAP7
Gene Name		transient receptor potential cation channel, subfamily V, member 4	microtubule-associated protein 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Integral Component Of Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane	Cytoplasm Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Basolateral Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Osmosensor Activity Protein Kinase C Binding Cation Channel Activity Calcium Channel Activity Calmodulin Binding ATP Binding Microtubule Binding Protein Kinase Binding SH2 Domain Binding Alpha-tubulin Binding Beta-tubulin Binding Actin Filament Binding	Receptor Binding Structural Molecule Activity
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Cell Volume Homeostasis Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Negative Regulation Of Neuron Projection Development Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Actin Cytoskeleton Reorganization Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Cortical Microtubule Organization Microtubule Polymerization Regulation Of Response To Osmotic Stress Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response	Microtubule Cytoskeleton Organization Response To Osmotic Stress Establishment Or Maintenance Of Cell Polarity Protein Localization To Plasma Membrane
Pathways		Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	3 interactors: POT1 TERF1 TRPV4
Entrez ID		59341	9053
HPRD ID		05667	04982
Ensembl ID		ENSG00000111199	ENSG00000135525
Uniprot IDs		Q9HBA0	B7Z3E1 B7Z3Y3 B7ZB64 Q14244
PDB IDs		4DX1 4DX2
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway T Cell Costimulation Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Protein Autophosphorylation Leukocyte Migration Innate Immune Response Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Vesicle-mediated Transport Membrane Tubulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Immune Response Response To Platelet-derived Growth Factor Regulation Of Vesicle-mediated Transport Regulation Of Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endocytosis Regulation Of Lymphocyte Activation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Peptide Hormone Regulation Of Defense Response To Virus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Response To Organonitrogen Compound Response To Peptide Immune Response Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Defense Response Ephrin Receptor Signaling Pathway Phagocytosis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Defense Response To Virus By Virus Viral Process Response To Hormone	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Organelle Organization Regulation Of DNA Replication Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of DNA Strand Elongation Cortical Microtubule Organization Osmosensory Signaling Pathway Regulation Of Microtubule-based Process Homeostatic Process Positive Regulation Of Cytoskeleton Organization Regulation Of Chromosome Organization Vasopressin Secretion Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening DNA Replication Telomere Maintenance Via Telomere Shortening Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Transferase Activity Cellular Component Assembly Regulation Of Cellular Component Organization Positive Regulation Of Helicase Activity Telomere Capping Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Response To Osmotic Stress Hyperosmotic Salinity Response Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Regulation Of Cytoskeleton Organization Positive Regulation Of Microtubule Polymerization
Tagcloud ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid
Tagcloud (Difference) ?		afferent afferents airway airways ankyrin antitussives arachidonic channels circumstances cough dangerous diseased gathered harmful impacting initiates lives melastatin nerves osmolarity reflex trpa trpm uncover unmet vagal vanilloid
Tagcloud (Intersection) ?