TRPV4 and PACSIN3

Number of citations of the paper that reports this interaction (PubMedID 16627472)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TRPV4	PACSIN3
Description		transient receptor potential cation channel subfamily V member 4	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Cell Projection Anchoring Junction	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Actin Binding Osmosensor Activity Protein Kinase C Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Diet Induced Thermogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Volume Homeostasis Response To Osmotic Stress Hypotonic Response Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Interleukin-6 Production Response To Insulin Monoatomic Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Glucose Homeostasis Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Positive Regulation Of Striated Muscle Contraction Positive Regulation Of JNK Cascade Microtubule Polymerization Regulation Of Response To Osmotic Stress Positive Regulation Of Inflammatory Response Multicellular Organismal-level Water Homeostasis Transmembrane Transport Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Cellular Hypotonic Salinity Response Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Energy Homeostasis Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Negative Regulation Of Brown Fat Cell Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		TRP channels High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Clathrin-mediated endocytosis
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia Distal hereditary motor neuropathies (dHMN) TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
GWAS		Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		59341	29763
HPRD ID		05667	05937
Ensembl ID		ENSG00000111199	ENSG00000165912
Uniprot IDs		Q9HBA0	Q9UKS6
PDB IDs		4DX1 4DX2 7AA5 8FC7 8FC8 8FC9 8FCA 8FCB 8JU5 8JU6 8JVI 8JVJ 8T1B 8T1C 8T1D 8T1E 8T1F
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus T Cell Costimulation Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Signaling Receptor Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Transport Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Transporter Binding Ephrin Receptor Signaling Pathway Phospholipase Activator Activity Plasma Membrane Tubulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune Response Activation Of Innate Immune Response Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Actin Filament Negative Regulation Of Immune Response Cellular Response To Lectin Cellular Response To Platelet-derived Growth Factor Stimulus Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Platelet-derived Growth Factor Ephrin Receptor Binding Positive Regulation Of T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Cell Migration	Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
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