ELOA and PLK4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ELOA	PLK4
Description		elongin A	polo like kinase 4
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Elongin Complex Site Of DNA Damage	XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cleavage Furrow Deuterosome Procentriole Procentriole Replication Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II	Protein Phosphorylation Centriole Replication Regulation Of Cell Cycle Process Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS
Interacting Genes		58 interacting genes: AXIN2 BACH2 BRCA1 CBY2 CCDC57 CDR2L CEP57L1 CEP70 CNTROB CUL5 DLGAP1-AS2 ELOB ERCC6 EVI5 FAM9B FCHO1 FXR1 GMCL1 GOLGA6A GRIPAP1 HIVEP1 HOMEZ JAKMIP2 KANK2 KLHL2 KRT40 KRTAP10-3 KXD1 LMNA LZTS1 MCC MDFI MED21 MID1 MID2 NAB2 NACC1 NAF1 NFKBID NINL OGT PER2 PLK4 PPFIA1 PRDM6 PRMT5 RABEP1 RAD54B RAP1A REXO1 RNF10 SIRPA SPECC1L TNIP1 TP53BP2 TRIM37 TRIM54 ZNF792	25 interacting genes: ACTR2 AIRIM ARR3 BTRC CHD3 CYLD DCAF1 DNAJB13 DRC4 ELOA MIR126 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		6924	10733
HPRD ID		02873	10387
Ensembl ID		ENSG00000011007	ENSG00000142731
Uniprot IDs		Q14241	O00444
PDB IDs		4HFX 6ZUZ 8OEV 8OEW 8OF0	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J 8XPG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cytoskeleton Organization Identical Protein Binding Regulation Of Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Regulation Of Cytoskeleton Organization Microtubule-based Process Centriole Replication Regulation Of Centriole Replication Regulation Of Protein Localization To Synapse Nuclear Pore Localization Regulation Of Receptor Localization To Synapse Centriole Assembly Negative Regulation Of Microtubule Depolymerization Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Activity Microtubule Organizing Center Organization Negative Regulation Of Supramolecular Fiber Organization Protein Ubiquitination Negative Regulation Of Centriole Replication Regulation Of Microtubule Depolymerization Cytoplasm Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Centrosome Duplication Protein Binding Negative Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Protein Localization To Microtubule Cytoskeleton XY Body Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cul5-RING Ubiquitin Ligase Complex Regulation Of RNA Metabolic Process	Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centrosome Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule Negative Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Poly(A) RNA Polymerase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process I-SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Microtubule Binding Regulation Of Extracellular Matrix Assembly Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Microtubule-based Process Regulation Of Cytoskeleton Organization Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Centriolar Satellite Regulation Of Primary Metabolic Process Ciliary Basal Body Phosphoprotein Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Neuron Fate Commitment Ventricular Septum Morphogenesis Nucleus Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?