TCEB3 and MED21

Number of citations of the paper that reports this interaction (PMID 9305922)
37

Data Source:
HPRD (in vitro)

		TCEB3	MED21
Gene Name		transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	mediator complex subunit 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane	Mediator Complex
	Molecular Function	DNA Binding	Transcription Coactivator Activity DNA-directed RNA Polymerase Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription	Blastocyst Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: BRCA1 CEP57L1 CEP70 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SPERT TCEB2 TRIM54	25 interactors: BLOC1S6 BRCA1 BTF3 CDK8 CDK9 ESR1 ESR2 HNF4A HTT MAGEB4 MED29 PCBD2 POLR2A SKP1 SSC5D TARBP2 TCEB3 TFG THRA THRB TP53 TRIM27 VAV2 ZNF655 ZSCAN1
Entrez ID		6924	9412
HPRD ID		02873	09156
Ensembl ID		ENSG00000011007	ENSG00000152944
Uniprot IDs		Q14241	F5H872 Q13503
PDB IDs		4HFX
Enriched GO Terms of Interacting Partners?		Regulation Of Viral Transcription Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Regulation Of Viral Process Regulation Of Microtubule-based Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Centrosome Duplication Cell Cycle Process Positive Regulation Of Viral Transcription Regulation Of Centrosome Cycle Centrosome Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Microtubule-based Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Centriole Replication Transcription, RNA-templated Positive Regulation Of Histone H3-K9 Acetylation Cell Cycle DNA-templated Transcription, Elongation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Centrosome Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stress Microtubule Organizing Center Organization Embryonic Placenta Development Microtubule Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Transcription, DNA-templated Maintenance Of Protein Location In Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Maintenance Of Protein Location Negative Regulation Of Centriole Replication Positive Regulation Of Centrosome Duplication Maintenance Of Location In Cell Cell Differentiation Regulation Of Cytoskeleton Organization Response To Stress Regulation Of RNA Metabolic Process In Utero Embryonic Development	Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Gene Expression Gene Expression Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Steroid Hormone Regulation Of Viral Process Positive Regulation Of Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Viral Process Response To Organic Cyclic Compound Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipid Female Courtship Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Secretion Response To Stimulus Rhythmic Process Cellular Response To Stimulus Mating
Tagcloud ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski	accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Difference) ?		anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski	accompanied beads blocking cadherin coactivator core defects differentiation drip drip205 facilitates glioma homolog hyperproliferation interacting keratinocyte keratinocytes med1 med10 mediator multisubunit newly oncogene promoting silencing subunit subunits vdr vitamin
Tagcloud (Intersection) ?