RABGGTB and RAB27A

Number of citations of the paper that reports this interaction (PMID 12802062)
33

Data Source:
HPRD (in vitro)

		RABGGTB	RAB27A
Gene Name		Rab geranylgeranyltransferase, beta subunit	RAB27A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Rab-protein Geranylgeranyltransferase Complex	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Geranylgeranylation	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion
Pathways			Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ALAS2 ARAF B4GALT7 CHML FAM19A1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A TMEM25 WDR4	28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16
Entrez ID		5876	5873
HPRD ID		01532	04845
Ensembl ID		ENSG00000137955	ENSG00000069974
Uniprot IDs		A8KAJ2 P53611 Q6IB63	A2RU94 P51159
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Intracellular Protein Transport Small GTPase Mediated Signal Transduction Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Exocytosis Intracellular Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Intracellular Signal Transduction Protein Localization Membrane Docking Establishment Of Localization In Cell Multivesicular Body Organization Vesicle-mediated Transport Protein Secretion Melanosome Transport Pigment Granule Transport Establishment Of Organelle Localization Establishment Of Melanosome Localization Regulation Of Endosome Size Melanosome Localization Cellular Localization Exosomal Secretion Organelle Localization Regulation Of Neuronal Synaptic Plasticity Cellular Pigmentation Endosomal Transport Vesicle Docking Involved In Exocytosis Secretion By Cell Vesicle Docking Secretion Regulation Of Secretion Positive Regulation Of Secretion Synaptic Vesicle Transport Cytoplasmic Transport Exocytosis Pigmentation Positive Regulation Of Regulated Secretory Pathway Early Endosome To Late Endosome Transport Endomembrane System Organization Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Endosome Organization Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling	Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization
Tagcloud ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Difference) ?			adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle
Tagcloud (Intersection) ?