RABGGTB and RAB37

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RABGGTB	RAB37
Description		Rab geranylgeranyltransferase subunit beta	RAB37, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cilium Cytoplasmic Vesicle Photoreceptor Connecting Cilium Azurophil Granule Membrane Specific Granule Membrane Cell Projection
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process	Positive Regulation Of Autophagy Protein Transport Regulation Of Exocytosis Regulation Of Eye Photoreceptor Cell Development
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Neutrophil degranulation RAB geranylgeranylation
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Neurological blood protein biomarker levels ( 31320639) Neutrophil count ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4	5 interacting genes: EWSR1 MAL2 RAB5A RABGGTB RIMS1
Entrez ID		5876	326624
HPRD ID		01532	06702
Ensembl ID		ENSG00000137955	ENSG00000172794
Uniprot IDs		A8KAJ2 P53611 Q6IB63	A0A9H3ZVF6 B3KPZ5 B7Z3L0 Q96AX2
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60
Enriched GO Terms of Interacting Partners?		G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway	Regulation Of Synaptic Vesicle Exocytosis Plasma Membrane Cytoplasmic Side Of Early Endosome Membrane Regulation Of Exocytosis Membrane Raft Regulation Of Neurotransmitter Secretion Protein Localization To Early Endosome Membrane Fusion Regulation Of Regulated Secretory Pathway Visual Perception Rab-protein Geranylgeranyltransferase Complex Protein Prenyltransferase Activity Sensory Perception Of Light Stimulus Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Acrosomal Vesicle Exocytosis Plasma Membrane To Endosome Transport Endomembrane System Vesicle-mediated Transport Intracellular Transport Amyloid-beta Clearance By Transcytosis Protein Geranylgeranylation Small GTPase Binding Prenyltransferase Activity Protein Prenylation Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Presynaptic Active Zone Organization Positive Regulation Of Inhibitory Postsynaptic Potential Structural Constituent Of Myelin Sheath Regulation Of Endosome Size Early Phagosome Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Protein Localization To Endosome Synaptic Vesicle Recycling Somatodendritic Compartment Guanyl Nucleotide Binding Synaptic Vesicle Priming Regulation Of Vesicle Size Transcytosis Positive Regulation Of Dendrite Extension Cellular Localization Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Amyloid-beta Clearance Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Sensory Perception
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