RABGGTB and RAB11A

Number of citations of the paper that reports this interaction (PubMedID 9719562)
0

Data Source:
HPRD (in vivo)

		RABGGTB	RAB11A
Description		Rab geranylgeranyltransferase subunit beta	RAB11A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Spindle Pole Cytoplasm Endosome Multivesicular Body Golgi Apparatus Trans-Golgi Network Centrosome Centriole Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Endocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Trans-Golgi Network Membrane Protein-containing Complex Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Recycling Endosome Glutamatergic Synapse
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Syntaxin Binding Myosin V Binding Dynein Light Intermediate Chain Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Microtubule-based Movement Mitotic Metaphase Chromosome Alignment Positive Regulation Of Epithelial Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Regulation Of Cytokinesis Protein Localization To Cell Surface Multivesicular Body Assembly Golgi To Plasma Membrane Protein Transport Positive Regulation Of Cilium Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Protein Localization To Cilium Protein Transmembrane Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Synaptic Vesicle Endosomal Processing Amyloid-beta Clearance By Transcytosis Regulation Of Cilium Assembly Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Protein Localization To Centrosome Protein Localization To Cleavage Furrow Exosomal Secretion Regulation Of Endocytic Recycling
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Vasopressin regulates renal water homeostasis via Aquaporins Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate	5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4	32 interacting genes: ARF6 CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB13 RAB3IL1 RAB3IP RAB8A RABGGTB RCHY1 SEC13 SNCA STX4 TBXA2R TDP2 WDR44
Entrez ID		5876	8766
HPRD ID		01532	05715
Ensembl ID		ENSG00000137955	ENSG00000103769
Uniprot IDs		A8KAJ2 P53611 Q6IB63	P62491
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P 4D0L 4D0M 4LWZ 4LX0 4UJ3 4UJ4 4UJ5 5C46 5C4G 5EUQ 5EZ5 5FBL 5FBQ 5FBR 5FBV 5FBW 5JCZ 6DJL 6IXV 8VOF
Enriched GO Terms of Interacting Partners?		G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway	Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Protein Localization Recycling Endosome Endosome Small GTPase Binding Recycling Endosome Membrane Organelle Localization Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Cellular Localization Organelle Localization By Membrane Tethering Membrane Docking Intracellular Transport Negative Regulation Of Adiponectin Secretion Endosomal Transport Post-Golgi Vesicle-mediated Transport Midbody Protein Localization To Plasma Membrane Cytosol Exocytosis Golgi To Plasma Membrane Transport Protein Localization To Cell Periphery Endocytic Recycling Cytoplasmic Vesicle Localization Within Membrane Kinetochore Golgi Vesicle Transport Cytoplasmic Vesicle Membrane Negative Regulation Of Cell Projection Organization Protein Localization To Membrane Neuron Projection Establishment Of Protein Localization To Plasma Membrane Golgi Apparatus Cytoplasm Vesicle Docking Synaptic Vesicle Regulation Of Protein Localization Organelle Assembly Organelle Organization Regulation Of Vesicle-mediated Transport Regulation Of Organelle Assembly Secretion By Cell Protein Localization To Cleavage Furrow Endocytic Vesicle Regulation Of Secretion By Cell Regulation Of Receptor Recycling Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Cell Communication
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