RABGGTB and ALAS2

Number of citations of the paper that reports this interaction (PubMedID 546546)
0

Data Source:
HPRD (in vivo)

		RABGGTB	ALAS2
Description		Rab geranylgeranyltransferase subunit beta	5'-aminolevulinate synthase 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme B Biosynthetic Process Intracellular Iron Ion Homeostasis Erythrocyte Differentiation Intracellular Oxygen Homeostasis Tetrapyrrole Biosynthetic Process Hemoglobin Biosynthetic Process Erythrocyte Development
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Heme biosynthesis
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate	Pyridoxal phosphate Glycine
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4	4 interacting genes: BANP GRB2 RABGGTB SUCLA2
Entrez ID		5876	212
HPRD ID		01532	02356
Ensembl ID		ENSG00000137955	ENSG00000158578
Uniprot IDs		A8KAJ2 P53611 Q6IB63	P22557
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	5QQQ 5QQR 5QQS 5QQT 5QQU 5QQV 5QQW 5QQX 5QQY 5QQZ 5QR0 5QR1 5QR2 5QR3 5QR4 5QR5 5QR6 5QR7 5QR8 5QR9 5QRA 5QRB 5QRC 5QRD 5QRE 5QT3 6HRH
Enriched GO Terms of Interacting Partners?		G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway	Guanyl-nucleotide Exchange Factor Adaptor Activity Grb2-EGFR Complex Succinyl-CoA Pathway Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (ADP-forming) Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Prenyltransferase Activity Succinyl-CoA Catabolic Process Neurotrophin TRKA Receptor Binding Protein Geranylgeranylation Branching Involved In Labyrinthine Layer Morphogenesis Catalytic Activity Prenyltransferase Activity Protein Prenylation Succinyl-CoA Metabolic Process Succinate Metabolic Process Insulin Receptor Substrate Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?