RABGGTB and B4GALT7

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RABGGTB	B4GALT7
Gene Name		Rab geranylgeranyltransferase, beta subunit	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Rab GTPase Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Galactosyltransferase Activity Manganese Ion Binding Xylosylprotein 4-beta-galactosyltransferase Activity
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Geranylgeranylation	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Cellular Protein Modification Process Protein N-linked Glycosylation Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Extracellular Fibril Organization Small Molecule Metabolic Process Negative Regulation Of Fibroblast Proliferation
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ALAS2 ARAF B4GALT7 CHML FAM19A1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A TMEM25 WDR4	3 interactors: KRTAP10-3 KRTAP10-7 RABGGTB
Entrez ID		5876	11285
HPRD ID		01532	05060
Ensembl ID		ENSG00000137955	ENSG00000027847
Uniprot IDs		A8KAJ2 P53611 Q6IB63	Q9UBV7
PDB IDs			4IRP 4IRQ
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Intracellular Protein Transport Small GTPase Mediated Signal Transduction Cellular Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Exocytosis Intracellular Transport Regulation Of Vesicle-mediated Transport Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Intracellular Signal Transduction Protein Localization Membrane Docking Establishment Of Localization In Cell Multivesicular Body Organization Vesicle-mediated Transport Protein Secretion Melanosome Transport Pigment Granule Transport Establishment Of Organelle Localization Establishment Of Melanosome Localization Regulation Of Endosome Size Melanosome Localization Cellular Localization Exosomal Secretion Organelle Localization Regulation Of Neuronal Synaptic Plasticity Cellular Pigmentation Endosomal Transport Vesicle Docking Involved In Exocytosis Secretion By Cell Vesicle Docking Secretion Regulation Of Secretion Positive Regulation Of Secretion Synaptic Vesicle Transport Cytoplasmic Transport Exocytosis Pigmentation Positive Regulation Of Regulated Secretory Pathway Early Endosome To Late Endosome Transport Endomembrane System Organization Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Endosome Organization Regulation Of Synaptic Vesicle Exocytosis Synaptic Vesicle Recycling	Protein Geranylgeranylation Protein Prenylation Visual Perception Sensory Perception Of Light Stimulus
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