RABGGTB and IGFBP6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RABGGTB	IGFBP6
Name		Rab geranylgeranyltransferase subunit beta	insulin like growth factor binding protein 6
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Transferase Activity Small GTPase Binding Metal Ion Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Visual Perception Protein Geranylgeranylation Protein Modification Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		N-Formylmethionine Farnesyl diphosphate Geranylgeranyl diphosphate	None
GWAS		Daytime sleep phenotypes ( 27126917 ) Serum metabolite levels ( 23093944 )	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 )
Novel Interactors		1 novel interactors: RPS6KA1	2 novel interactors: DDX10 ERBB3
Interacting Genes		19 interacting genes: ALAS2 ARAF B4GALT7 CHML IGFBP6 NPSR1 PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A SH3GLB1 TAFA1 TMEM25 WDR4	38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		5876	3489
HPRD ID		01532	00902
Ensembl ID		ENSG00000137955	ENSG00000167779
Uniprot IDs		A8KAJ2 P53611 Q6IB63	F8VVA5 P24592
PDB IDs		6J6X 6J74 6J7F 6J7X 6O60	1RMJ 2JM2
GO Terms Enriched among Interactors		G Protein Activity GTPase Activity Myosin V Binding GTP Binding Endosome Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Synaptic Vesicle Recycling Protein Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Exocytosis Positive Regulation Of Exocytosis Pigment Granule Localization Establishment Of Protein Localization Nucleotide Binding Exosomal Secretion Intracellular Protein Localization Organelle Localization Synaptic Vesicle Membrane Vesicle-mediated Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Hydrolase Activity Presynaptic Endosome Regulation Of Neuronal Synaptic Plasticity Regulation Of Secretion Plasma Membrane To Endosome Transport Golgi Apparatus GDP Binding Endosome To Plasma Membrane Protein Transport Phagocytic Vesicle Neurotransmitter Receptor Transport Regulation Of Plasma Membrane Organization Vesicle-mediated Transport In Synapse Establishment Of Localization In Cell Secretory Granule Membrane Endosomal Transport Melanosome Transcytosis Melanosome Membrane Positive Regulation Of Secretion By Cell Early Endosome To Late Endosome Transport Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway	Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance