PVRL1 and PRNP

Number of citations of the paper that reports this interaction (PMID 15146195)
32

Data Source:
HPRD (in vivo)

		PVRL1	PRNP
Gene Name		poliovirus receptor-related 1 (herpesvirus entry mediator C)	prion protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Cell-cell Adherens Junction Membrane Integral Component Of Membrane Catenin Complex Axon Growth Cone Membrane Presynaptic Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Protein Homodimerization Activity Virion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Axon Guidance Response To Virus Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs			Tetracycline
Diseases
GWAS			Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		6 interactors: MLLT4 PARD3 PRNP PVR PVRL3 PVRL4	76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740
Entrez ID		5818	5621
HPRD ID		07200	01453
Ensembl ID		ENSG00000110400	ENSG00000171867
Uniprot IDs		Q15223	B2NI04 F7VJQ1 P04156 Q53YK7
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cellular Component Assembly Cell Adhesion Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Epithelial Cell Development Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cellular Response To Copper Ion Apical Constriction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Establishment Of Endothelial Intestinal Barrier Asymmetric Cell Division Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Interleukin-17 Production Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Protein Phosphorylation Locomotion Positive Regulation Of Myelination Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Phosphorylation Positive Regulation Of Rap GTPase Activity Movement Of Cell Or Subcellular Component Establishment Of Epithelial Cell Polarity Negative Regulation Of Interleukin-2 Production Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Copper Ion Regulation Of Rap GTPase Activity Copper Ion Homeostasis Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Regulation Of Rap Protein Signal Transduction Single Organismal Cell-cell Adhesion Axonogenesis Establishment Of Endothelial Barrier Epithelial Cell Differentiation Lens Morphogenesis In Camera-type Eye Cell Development Viral Process Centrosome Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Interferon-gamma Production	Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization
Tagcloud ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses	chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Difference) ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses	chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Intersection) ?