PVRL1 and PVRL4

Number of citations of the paper that reports this interaction (PMID 12011057)
30

Data Source:
HPRD (in vitro)

		PVRL1	PVRL4
Gene Name		poliovirus receptor-related 1 (herpesvirus entry mediator C)	poliovirus receptor-related 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Cell-cell Adherens Junction Membrane Integral Component Of Membrane Catenin Complex Axon Growth Cone Membrane Presynaptic Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Protein Homodimerization Activity Virion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Axon Guidance Response To Virus Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization	Cell Adhesion Viral Process Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions	Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: MLLT4 PARD3 PRNP PVR PVRL3 PVRL4	5 interactors: MLLT4 PICK1 PVRL1 PVRL2 TIGIT
Entrez ID		5818	81607
HPRD ID		07200	17934
Ensembl ID		ENSG00000110400	ENSG00000143217
Uniprot IDs		Q15223	K4PZ75 Q96NY8
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cellular Component Assembly Cell Adhesion Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Epithelial Cell Development Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cellular Response To Copper Ion Apical Constriction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Establishment Of Endothelial Intestinal Barrier Asymmetric Cell Division Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Interleukin-17 Production Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Protein Phosphorylation Locomotion Positive Regulation Of Myelination Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Phosphorylation Positive Regulation Of Rap GTPase Activity Movement Of Cell Or Subcellular Component Establishment Of Epithelial Cell Polarity Negative Regulation Of Interleukin-2 Production Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Copper Ion Regulation Of Rap GTPase Activity Copper Ion Homeostasis Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Regulation Of Rap Protein Signal Transduction Single Organismal Cell-cell Adhesion Axonogenesis Establishment Of Endothelial Barrier Epithelial Cell Differentiation Lens Morphogenesis In Camera-type Eye Cell Development Viral Process Centrosome Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Interferon-gamma Production	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Cell Development Interaction With Host Coreceptor-mediated Virion Attachment To Host Cell Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Viral Life Cycle Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Cell Adhesion Establishment Of Endothelial Intestinal Barrier Enamel Mineralization Virion Attachment To Host Cell DNA Methylation Involved In Embryo Development Positive Regulation Of Immune Response To Tumor Cell Dendritic Spine Maintenance Adhesion Of Symbiont To Host Cell Differentiation Tooth Mineralization Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Desmosome Organization Positive Regulation Of Mast Cell Activation Negative Regulation Of Actin Nucleation Acrosome Assembly Amelogenesis Establishment Of Mitochondrion Localization Positive Regulation Of Rap GTPase Activity Long Term Synaptic Depression Regulation Of Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Component Assembly Negative Regulation Of Interleukin-12 Production Dendritic Spine Organization Regulation Of Rap GTPase Activity DNA Methylation Involved In Gamete Generation
Tagcloud ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses
Tagcloud (Difference) ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses
Tagcloud (Intersection) ?