PRNP and WDR5

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		PRNP	WDR5
Gene Name		prion protein	WD repeat domain 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Histone Methyltransferase Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding	Protein Binding Histone Methyltransferase Activity (H3-K4 Specific) Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport	Skeletal System Development Chromatin Organization Transcription, DNA-templated Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Histone H3-K4 Methylation
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines HATs acetylate histones RMTs methylate histone arginines
Drugs		Tetracycline
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740	23 interactors: APP ATN1 CHD8 HIST1H1C HIST4H4 HSF2 IKBKG KMT2A KMT2B KMT2C MBIP MLLT1 POU5F1 PRMT5 PRNP RUSC1-AS1 SETD1A SETD1B SRPK2 SSX2IP TERF2IP TP53 ZXDC
Entrez ID		5621	11091
HPRD ID		01453	10614
Ensembl ID		ENSG00000171867	ENSG00000196363
Uniprot IDs		B2NI04 F7VJQ1 P04156 Q53YK7	P61964
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I	2CNX 2CO0 2G99 2G9A 2GNQ 2H13 2H14 2H68 2H6K 2H6N 2H6Q 2H9L 2H9M 2H9N 2H9P 2O9K 3EG6 3EMH 3MXX 3N0D 3N0E 3P4F 3PSL 3SMR 3UR4 3UVK 3UVL 3UVM 3UVN 3UVO 4A7J 4ERQ 4ERY 4ERZ 4ES0 4ESG 4EWR 4GM3 4GM8 4IA9
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization	Gene Expression Chromatin Organization Regulation Of RNA Metabolic Process Chromosome Organization RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Histone H3-K4 Methylation RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Methylation Histone Modification Chromatin Modification Cellular Nitrogen Compound Metabolic Process Protein Methylation Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organelle Organization Methylation Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Chromosome Organization Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Regulation Of Transcription From RNA Polymerase II Promoter Neuron Apoptotic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Death Cellular Metabolic Process Histone H3-K4 Trimethylation DNA Conformation Change Regulation Of Organelle Organization Cellular Copper Ion Homeostasis Regulation Of Fibroblast Apoptotic Process
Tagcloud ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad
Tagcloud (Difference) ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	acidic allosterically ash2l box compass composed concave dpy30 erythroid forming heterodimer interface kmt2 lysine methyltransferase methyltransferases mll1 mutational rbbp5 referred ryanodine set1 spia spry stimulates switch trithorax trxg wrad
Tagcloud (Intersection) ?