PRNP and APLP2

Number of citations: 0 (PubMedID 15146195)
Data Source: HPRD (in vivo)

		PRNP	APLP2
Name		prion protein (Kanno blood group)	amyloid beta precursor like protein 2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Inclusion Body Extrinsic Component Of Membrane Dendrite Nuclear Membrane Terminal Bouton Membrane Raft Extracellular Exosome Side Of Membrane Postsynapse	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Platelet Alpha Granule Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Protein Binding Lamin Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity Cupric Ion Binding Cuprous Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Copper Ion Homeostasis Response To Oxidative Stress Learning Or Memory Long-term Memory Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Copper Ion Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Regulation Of Cell Cycle Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Cellular Response To Xenobiotic Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	G Protein-coupled Receptor Signaling Pathway Axonogenesis Central Nervous System Development
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Tetracycline Copper	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)	None
GWAS		Creutzfeldt-Jakob disease ( 19081515 ) Creutzfeldt-Jakob disease (sporadic) ( 25918841 32949544 ) Creutzfeldt-Jakob disease (variant) ( 22137330 ) KANNO antigen negativity ( 31020675 ) Platelet aggregation ( 20526338 ) Prion diseases ( 22210626 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI (smoking interaction) ( 28443625 )	Blood protein levels ( 30072576 )
Interacting Genes		93 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B CAV1 CCDC149 CCR1 CHLSN CLSTN1 CLU CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FZD7 GRB2 GRSF1 HAX1 HSPA5 HSPD1 IER3 IGF1R KIAA1191 KIFAP3 L1CAM LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SKIC8 SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	25 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 GNAO1 HGS HLA-A JUN JUNB KAT5 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 UBC VKORC1 ZNF512B
Entrez ID		5621	334
HPRD ID		01453	00103
Ensembl ID		ENSG00000171867	ENSG00000084234
Uniprot IDs		F7VJQ1 P04156 Q53YK7	A0A140VJE9 B4E3I5 Q06481
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR 7DWV 7FHQ 7RL4 7RVC 7RVE 7RVJ 7RVK 7RVL 7UMQ 7UN5	5JBT 5TPT 8RQ6
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex Amyloid-beta Binding Cell Adhesion Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Apoptotic Process Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Neuroblast Polarity Cellular Response To Interleukin-7 Response To Interleukin-7 Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Amyloid Fibril Formation Negative Regulation Of Programmed Cell Death Misfolded Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromaffin Granule Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Inclusion Body Assembly Enzyme Binding Low-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Formation Protein Refolding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Life Cycle Plasma Membrane MRNA Metabolic Process Cholesterol Transport RNA Binding Regulation Of Blood Coagulation Protein Import Regulation Of Apoptotic Process Regulation Of Hemostasis Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction COP9 Signalosome Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cholesterol Metabolic Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Catabolic Process Sterol Transport Protein Folding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Gene Expression Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Leading Edge Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization Apoptotic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Peptidyl-threonine Phosphorylation Programmed Cell Death Cell Death Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Macromolecule Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Localization To Site Of Double-strand Break Amyloid-beta Binding Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Establishment Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Response To Lipid Response To Steroid Hormone Regulation Of Cell Adhesion Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signaling Cassette Integrated Stress Response Signaling Transcription Factor AP-1 Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II