PRNP and AGO1

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		PRNP	AGO1
Gene Name		prion protein	argonaute RISC catalytic component 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Cytosol Polysome Ribonucleoprotein Complex Micro-ribonucleoprotein Complex
	Molecular Function	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Binding Endoribonuclease Activity Protein Binding MiRNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport	Nuclear-transcribed MRNA Catabolic Process Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression MiRNA Metabolic Process Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by NOTCH MicroRNA (miRNA) biogenesis Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System PIP3 activates AKT signaling Oncogene Induced Senescence PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Transcriptional regulation by small RNAs Signalling by NGF Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by FGFR Ca2+ pathway Oxidative Stress Induced Senescence Small interfering RNA (siRNA) biogenesis
Drugs		Tetracycline
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740	7 interactors: AGO2 DCP1A DCP2 DICER1 KHDRBS1 PRNP RELA
Entrez ID		5621	26523
HPRD ID		01453	06942
Ensembl ID		ENSG00000171867	ENSG00000092847
Uniprot IDs		B2NI04 F7VJQ1 P04156 Q53YK7	Q5TA58 Q9UL18
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I	1SI2 1SI3 4KRE 4KRF 4KXT
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization	Positive Regulation Of Schwann Cell Differentiation Regulation Of Schwann Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of MiRNA Metabolic Process RNA Interference Pre-miRNA Processing MRNA Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Metabolic Process Gene Silencing By MiRNA Positive Regulation Of Glial Cell Differentiation Cellular Response To DsRNA Posttranscriptional Gene Silencing Gene Expression Nucleic Acid Phosphodiester Bond Hydrolysis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Gliogenesis Negative Regulation Of Cellular Metabolic Process Gene Silencing By RNA Cellular Response To Organic Cyclic Compound RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Regulation Of Translational Initiation Regulation Of Glial Cell Differentiation Response To DsRNA Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Hair Follicle Cell Proliferation Acetaldehyde Metabolic Process Conversion Of Ds SiRNA To Ss SiRNA Nucleobase-containing Compound Metabolic Process Hair Follicle Development Hair Cycle Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Gliogenesis Gene Silencing Heterocycle Metabolic Process Hair Cycle Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation
Tagcloud ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly
Tagcloud (Difference) ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing syne2 unexpectedly
Tagcloud (Intersection) ?