PRNP and ADAM23

Number of citations of the paper that reports this interaction (PMID 15146195)
32

Data Source:
HPRD (in vivo)

		PRNP	ADAM23
Gene Name		prion protein	ADAM metallopeptidase domain 23
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport	Proteolysis Cell Adhesion Central Nervous System Development
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs		Tetracycline
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)	Bipolar disorder and schizophrenia ( 22688191)
Protein-Protein Interactions		76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740	1 interactors: PRNP
Entrez ID		5621	8745
HPRD ID		01453	04752
Ensembl ID		ENSG00000171867	ENSG00000114948
Uniprot IDs		B2NI04 F7VJQ1 P04156 Q53YK7	O75077
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization	Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Interleukin-17 Production Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Response To Copper Ion Copper Ion Homeostasis Negative Regulation Of Interferon-gamma Production Regulation Of Activated T Cell Proliferation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium-mediated Signaling Regulation Of T Cell Receptor Signaling Pathway Response To Cadmium Ion Regulation Of Potassium Ion Transport Negative Regulation Of T Cell Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Regulation Of Interferon-gamma Production Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Metal Ion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Cellular Response To Inorganic Substance Regulation Of T Cell Proliferation Cell Cycle Arrest Transition Metal Ion Homeostasis Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Adhesion Negative Regulation Of Cytokine Production Protein Homooligomerization Learning Or Memory Cognition Regulation Of T Cell Activation Negative Regulation Of Protein Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Metal Ion Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Axon Guidance Regulation Of Lymphocyte Activation Negative Regulation Of Phosphorylation Cellular Metal Ion Homeostasis
Tagcloud ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	adenomatous apc bc bcs cumulative cxcl12 detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Difference) ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	adenomatous apc bc bcs cumulative cxcl12 detecting disintegrin hypermethylation informative invasiveness lnms maintaining manifested metalloprotease methylated methylation methylations pl polyposis pts pyrosequencing quantification quantify rassf1a software spectrums spss utility
Tagcloud (Intersection) ?