NECTIN1 and NECTIN3

Number of citations of the paper that reports this interaction (PubMedID 12011057)
0

Data Source:
HPRD (in vitro)

		NECTIN1	NECTIN3
Description		nectin cell adhesion molecule 1	nectin cell adhesion molecule 3
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Axon Dendrite Growth Cone Membrane Presynaptic Membrane Cell Projection Apical Junction Complex Cell-cell Contact Zone Synapse Presynaptic Active Zone Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Synapse Postsynaptic Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Symbiont Entry Into Host Cell Camera-type Eye Morphogenesis Regulation Of Synapse Organization Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cochlea Morphogenesis Cell-cell Adhesion Protein Localization To Cell Junction	Lens Morphogenesis In Camera-type Eye Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fertilization Symbiont Entry Into Host Cell Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Cochlea Morphogenesis Cell-cell Adhesion Regulation Of Postsynapse Assembly Protein Localization To Cell Junction
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS			Feeling hurt ( 29500382)
Interacting Genes		10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR	24 interacting genes: AFDN CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-9 KRTAP9-3 NBPF19 NECTIN1 NECTIN2 NOTCH2NLA OTX1 PARD3 PICK1 PVR RGS20 TIGIT
Entrez ID		5818	25945
HPRD ID		07200	08454
Ensembl ID		ENSG00000110400	ENSG00000177707
Uniprot IDs		Q15223	Q9NQS3
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF 4MYW	4FOM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Cell Adhesion Mediator Activity Adherens Junction Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Symbiont Entry Into Host Cell Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Biological Process Involved In Interaction With Host Plasma Membrane Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Kinase Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Fibroblast Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Endochondral Bone Growth Biomineral Tissue Development Cell Adhesion Molecule Binding Branching Involved In Salivary Gland Morphogenesis Signal Transduction Positive Regulation Of Hydrolase Activity Bone Growth Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Postsynapse Organization Cell Adhesion Mesenchymal Cell Proliferation Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Apical Junction Complex Cell-cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Receptor Complex Identical Protein Binding Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Cell-cell Junction Positive Regulation Of Heart Growth Establishment Of Protein Localization To Membrane Tight Junction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Intermediate Filament Keratin Filament Susceptibility To T Cell Mediated Cytotoxicity Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell Adhesion Molecule Binding Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Identical Protein Binding Cell Adhesion Mediator Activity Adherens Junction Leukocyte Mediated Cytotoxicity Hair Cycle Virus Receptor Activity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cytosol Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Tight Junction Diencephalon Morphogenesis Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Bicellular Tight Junction Assembly Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Organization Cell Killing Tight Junction Assembly Tight Junction Organization Regulation Of Lymphocyte Mediated Immunity Sperm Mitochondrion Organization BBSome Binding Cell-cell Junction Coreceptor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
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