PRNP and HAX1

Number of citations of the paper that reports this interaction (PubMedID 21301993)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PRNP	HAX1
Description		prion protein (Kanno blood group)	HCLS1 associated protein X-1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Inclusion Body Extrinsic Component Of Membrane Dendrite Nuclear Membrane Terminal Bouton Membrane Raft Extracellular Exosome Side Of Membrane Postsynapse	P-body Nucleus Nuclear Envelope Transcription Regulator Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Protein Binding Lamin Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity Cupric Ion Binding Cuprous Ion Binding	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Signaling Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Copper Ion Homeostasis Response To Oxidative Stress Learning Or Memory Long-term Memory Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Copper Ion Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Regulation Of Cell Cycle Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Cellular Response To Xenobiotic Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	Mitochondrion Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		Tetracycline Copper
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 25918841 32949544) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		93 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B CAV1 CCDC149 CCR1 CHLSN CLSTN1 CLU CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FZD7 GRB2 GRSF1 HAX1 HSPA5 HSPD1 IER3 IGF1R KIAA1191 KIFAP3 L1CAM LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SKIC8 SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL WEE2-AS1 YWHAQ ZNF420
Entrez ID		5621	10456
HPRD ID		01453	12075
Ensembl ID		ENSG00000171867	ENSG00000143575
Uniprot IDs		F7VJQ1 P04156 Q53YK7	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR 7DWV 7FHQ 7RL4 7RVC 7RVE 7RVJ 7RVK 7RVL 7UMQ 7UN5
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex Amyloid-beta Binding Cell Adhesion Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Apoptotic Process Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Neuroblast Polarity Cellular Response To Interleukin-7 Response To Interleukin-7 Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Amyloid Fibril Formation Negative Regulation Of Programmed Cell Death Misfolded Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromaffin Granule Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Inclusion Body Assembly Enzyme Binding Low-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Formation Protein Refolding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Life Cycle Plasma Membrane MRNA Metabolic Process Cholesterol Transport RNA Binding Regulation Of Blood Coagulation Protein Import Regulation Of Apoptotic Process Regulation Of Hemostasis Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction COP9 Signalosome Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cholesterol Metabolic Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Catabolic Process Sterol Transport Protein Folding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Ceramide Floppase Activity Ceramide Translocation Cytosol Regulation Of Transport Sphingolipid Translocation Phosphatidylcholine Floppase Activity ABC-type Transporter Activity Intercellular Canaliculus Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Transmembrane Transporter Binding Dendritic Spine Maintenance ATPase-coupled Intramembrane Lipid Transporter Activity Regulation Of Interleukin-2 Production Homeostatic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Regulation Of Calcium Ion Import Across Plasma Membrane RNA Polymerase I Complex Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Ceramide Transport Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Cytoplasm Negative Regulation Of Monoatomic Ion Transport Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Dendritic Spine Organization Response To Copper Ion Multicellular Organismal-level Homeostasis Positive Regulation Of Interleukin-2 Production Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Phospholipid Translocation ATPase-coupled Transmembrane Transporter Activity Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Transmembrane Transport Type 8 Metabotropic Glutamate Receptor Binding
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