PRNP and IER3

Number of citations: 0 (PubMedID 18482256)
Data Source: BioGRID (pull down)

		PRNP	IER3
Name		prion protein (Kanno blood group)	immediate early response 3
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Postsynaptic Density Membrane Inclusion Body Extrinsic Component Of Membrane Dendrite Nuclear Membrane Terminal Bouton Membrane Raft Extracellular Exosome Side Of Membrane Postsynapse	Nucleus Mitochondrion Cytosol Membrane
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Protein Binding Lamin Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding ATP-dependent Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Activator Activity Molecular Condensate Scaffold Activity Cupric Ion Binding Cuprous Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Copper Ion Homeostasis Response To Oxidative Stress Learning Or Memory Long-term Memory Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Copper Ion Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Regulation Of Cell Cycle Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Cellular Response To Xenobiotic Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Regulation Of DNA Repair Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Tetracycline Copper	None
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)	None
GWAS		Creutzfeldt-Jakob disease ( 19081515 ) Creutzfeldt-Jakob disease (sporadic) ( 25918841 32949544 ) Creutzfeldt-Jakob disease (variant) ( 22137330 ) KANNO antigen negativity ( 31020675 ) Platelet aggregation ( 20526338 ) Prion diseases ( 22210626 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI (smoking interaction) ( 28443625 )	Age-related macular degeneration ( 23455636 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Chronic obstructive pulmonary disease ( 30804561 ) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311 ) Rosacea symptom severity ( 29771307 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Serum alkaline phosphatase levels ( 33547301 ) Sleep duration ( 25469926 ) Small cell lung carcinoma ( 28604730 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 20848476 )
Interacting Genes		93 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B CAV1 CCDC149 CCR1 CHLSN CLSTN1 CLU CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FZD7 GRB2 GRSF1 HAX1 HSPA5 HSPD1 IER3 IGF1R KIAA1191 KIFAP3 L1CAM LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SKIC8 SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2
Entrez ID		5621	8870
HPRD ID		01453	04295
Ensembl ID		ENSG00000171867	ENSG00000137331
Uniprot IDs		F7VJQ1 P04156 Q53YK7	A0A1U9X7X2 P46695
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR 7DWV 7FHQ 7RL4 7RVC 7RVE 7RVJ 7RVK 7RVL 7UMQ 7UN5	Not available
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex Amyloid-beta Binding Cell Adhesion Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Apoptotic Process Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Neuroblast Polarity Cellular Response To Interleukin-7 Response To Interleukin-7 Regulation Of Programmed Cell Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Amyloid Fibril Formation Negative Regulation Of Programmed Cell Death Misfolded Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromaffin Granule Cell Projection Organization Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Inclusion Body Assembly Enzyme Binding Low-density Lipoprotein Particle Receptor Binding Signaling Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Formation Protein Refolding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Life Cycle Plasma Membrane MRNA Metabolic Process Cholesterol Transport RNA Binding Regulation Of Blood Coagulation Protein Import Regulation Of Apoptotic Process Regulation Of Hemostasis Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction COP9 Signalosome Positive Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cholesterol Metabolic Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Catabolic Process Sterol Transport Protein Folding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process	Cellular Response To Copper Ion Interleukin-34-mediated Signaling Pathway Response To Copper Ion Response To Growth Factor Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Identical Protein Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Intracellular Monoatomic Cation Homeostasis Regulation Of Proteolysis Glial Cell Development Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Monoatomic Ion Homeostasis Bergmann Glial Cell Differentiation Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Copper Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Phosphatase Type 2A Complex MAP Kinase Activity Chemical Homeostasis Learning Or Memory Intracellular Chemical Homeostasis Regulation Of Cellular Localization Regulation Of Golgi Organization Pseudopodium Protein Phosphatase Activator Activity Regulation Of Early Endosome To Late Endosome Transport Copper Ion Homeostasis Schwann Cell Development Endoplasmic Reticulum Lumen Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity