PVRL1 and MLLT4

Number of citations of the paper that reports this interaction (PMID 10225955)
110

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PVRL1	MLLT4
Gene Name		poliovirus receptor-related 1 (herpesvirus entry mediator C)	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Cell-cell Adherens Junction Membrane Integral Component Of Membrane Catenin Complex Axon Growth Cone Membrane Presynaptic Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Cell Junction Apical Part Of Cell
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Protein Homodimerization Activity Virion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding	Protein Binding Protein C-terminus Binding Ras GTPase Binding Cell Adhesion Molecule Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Axon Guidance Response To Virus Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Viral Entry Into Host Cell Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Rap GTPase Activity Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Establishment Of Endothelial Intestinal Barrier
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS			Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		6 interactors: MLLT4 PARD3 PRNP PVR PVRL3 PVRL4	37 interactors: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NRXN1 NRXN2 NRXN3 PFN1 PICK1 PVRL1 PVRL2 PVRL3 PVRL4 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		5818	4301
HPRD ID		07200	01164
Ensembl ID		ENSG00000110400	ENSG00000130396
Uniprot IDs		Q15223	P55196
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF	1T2M 1XZ9 2AIN 2EXG
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cellular Component Assembly Cell Adhesion Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Epithelial Cell Development Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cellular Response To Copper Ion Apical Constriction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Establishment Of Endothelial Intestinal Barrier Asymmetric Cell Division Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Interleukin-17 Production Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Protein Phosphorylation Locomotion Positive Regulation Of Myelination Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Phosphorylation Positive Regulation Of Rap GTPase Activity Movement Of Cell Or Subcellular Component Establishment Of Epithelial Cell Polarity Negative Regulation Of Interleukin-2 Production Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Copper Ion Regulation Of Rap GTPase Activity Copper Ion Homeostasis Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Regulation Of Rap Protein Signal Transduction Single Organismal Cell-cell Adhesion Axonogenesis Establishment Of Endothelial Barrier Epithelial Cell Differentiation Lens Morphogenesis In Camera-type Eye Cell Development Viral Process Centrosome Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Interferon-gamma Production	Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Anatomical Structure Development Developmental Process Cell Development Cell Projection Organization Signal Transduction Nervous System Development Axon Development Cellular Response To Stimulus Generation Of Neurons Anatomical Structure Morphogenesis Neurogenesis Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Cell Part Morphogenesis System Development Cell Differentiation Neuron Differentiation Ras Protein Signal Transduction Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Neuron Projection Development Neuron Projection Morphogenesis Locomotion Cell Projection Morphogenesis Regulation Of Signaling Cell Junction Assembly Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Regulation Of Cellular Component Organization Cell Adhesion Chemotaxis Small GTPase Mediated Signal Transduction Movement Of Cell Or Subcellular Component Cell Morphogenesis Response To External Stimulus Adherens Junction Organization Cellular Component Assembly Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Regulation Of Synapse Assembly Cellular Response To Organic Substance Response To Organic Substance Learning
Tagcloud ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Difference) ?		11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas cnot2 glipr1l1 mec mecs mucoepidermoid numa1 pax5 rab3ip sdc statuses	abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt6 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16
Tagcloud (Intersection) ?