PRNP and DYRK3

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		PRNP	DYRK3
Gene Name		prion protein	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Erythrocyte Differentiation
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs		Tetracycline
Diseases
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740	3 interactors: FBXO25 NEDD4L PRNP
Entrez ID		5621	8444
HPRD ID		01453	04607
Ensembl ID		ENSG00000171867	ENSG00000143479
Uniprot IDs		B2NI04 F7VJQ1 P04156 Q53YK7	O43781
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I
Enriched GO Terms of Interacting Partners?		Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Response To Metal Ion Cellular Response To Copper Ion Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Calcium-mediated Signaling Cellular Metal Ion Homeostasis Regulation Of Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Cellular Cation Homeostasis Cellular Ion Homeostasis Negative Regulation Of Interleukin-17 Production Metal Ion Homeostasis Response To Inorganic Substance Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Sodium Ion Transport Negative Regulation Of Activated T Cell Proliferation Cellular Chemical Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Sodium Ion Homeostasis Ion Homeostasis Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Negative Regulation Of Interleukin-2 Production Ventricular Cardiac Muscle Cell Action Potential Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Response To Copper Ion Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Repolarization Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Copper Ion Homeostasis Sodium Ion Homeostasis Regulation Of Protein Localization Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transporter Activity Chemical Homeostasis Positive Regulation Of Cation Channel Activity Negative Regulation Of Interferon-gamma Production
Tagcloud ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	accessibility caps chromatin deficient digestion diminished dnase drosophila flies fourth harboring hp1a hypersensitive inserted interspersed marks melanogaster methylated nuclease opening paradoxically possessed promoters repressive revealing silenced stock surprising transgene
Tagcloud (Difference) ?		chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols	accessibility caps chromatin deficient digestion diminished dnase drosophila flies fourth harboring hp1a hypersensitive inserted interspersed marks melanogaster methylated nuclease opening paradoxically possessed promoters repressive revealing silenced stock surprising transgene
Tagcloud (Intersection) ?