NECTIN1 and PVR

Number of citations of the paper that reports this interaction (PubMedID 12011057)
0

Data Source:
HPRD (in vitro)

		NECTIN1	PVR
Description		nectin cell adhesion molecule 1	PVR cell adhesion molecule
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Adherens Junction Membrane Axon Dendrite Growth Cone Membrane Presynaptic Membrane Cell Projection Apical Junction Complex Cell-cell Contact Zone Synapse Presynaptic Active Zone Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Carbohydrate Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Virion Binding Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity	Virus Receptor Activity Protein Binding Signaling Receptor Activity Receptor Ligand Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Desmosome Organization Iron Ion Transport Immune Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Axon Guidance Symbiont Entry Into Host Cell Camera-type Eye Morphogenesis Regulation Of Synapse Organization Regulation Of Synapse Assembly Retina Development In Camera-type Eye Enamel Mineralization Cochlea Morphogenesis Cell-cell Adhesion Protein Localization To Cell Junction	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Symbiont Entry Into Host Cell Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization
Drugs			Sphingosine Myristic acid
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS			Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet distribution width ( 32888494)
Interacting Genes		10 interacting genes: AFDN CBL FGFR1 FGFR2 FGFR3 NECTIN3 NECTIN4 PARD3 PRNP PVR	68 interacting genes: ADIPOQ ANKRD46 AP1M2 AQP10 BRICD5 C3orf52 CD226 CD47 CD96 CLDN19 CTXN3 CYB561A3 CYSRT1 DYNLT1 DYNLT3 EBP EDDM3B GPRC5D HHATL HOXA1 INSIG2 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-3 KRTAP9-3 MFSD11 NBPF19 NECTIN1 NECTIN3 NINJ1 NINJ2 NOTCH2NLA OLFM4 PGA4 PLA2G3 PLP2 PLPP6 RUSF1 SCD SLC30A2 SLC35B4 SLC41A2 SMIM1 SNAP47 SYS1 TAS2R19 TIGIT TM6SF2 TMBIM6 TMEM147 TMEM229B TMEM54 TMEM65 TMEM79 TSPO VAMP5 VTN WNK1 ZDHHC15 ZDHHC22 ZFPL1 ZFTRAF1
Entrez ID		5818	5817
HPRD ID		07200	01434
Ensembl ID		ENSG00000110400	ENSG00000073008
Uniprot IDs		Q15223	A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151
PDB IDs		3ALP 3SKU 3U82 3U83 4FMF 4MYW	1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Positive Regulation Of Lipase Activity Cell Adhesion Mediator Activity Adherens Junction Fibroblast Growth Factor Binding Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Symbiont Entry Into Host Cell Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Biological Process Involved In Interaction With Host Plasma Membrane Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Kinase Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Fibroblast Growth Factor Receptor Signaling Pathway Lung-associated Mesenchyme Development Endochondral Bone Growth Biomineral Tissue Development Cell Adhesion Molecule Binding Branching Involved In Salivary Gland Morphogenesis Signal Transduction Positive Regulation Of Hydrolase Activity Bone Growth Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Postsynapse Organization Cell Adhesion Mesenchymal Cell Proliferation Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Apical Junction Complex Cell-cell Adhesion Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Receptor Complex Identical Protein Binding Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Cell-cell Junction Positive Regulation Of Heart Growth Establishment Of Protein Localization To Membrane Tight Junction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Keratin Filament Intermediate Filament Apical Junction Complex Membrane Cell Adhesion Mediator Activity Establishment Of Protein Localization To Membrane Identical Protein Binding Membrane Destabilizing Activity Regulation Of Natural Killer Cell Mediated Immunity Cell-cell Contact Zone Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cochlea Morphogenesis Regeneration Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Protein Binding Cell Adhesion Positive Regulation Of Mast Cell Activation Steroid Biosynthetic Process Cholesterol Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?