RBM4 and MIR25

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		RBM4	MIR25
Description		RNA binding motif protein 4	microRNA 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Perinuclear Region Of Cytoplasm	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Cyclin Binding MiRNA Binding Pre-mRNA Binding Metal Ion Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation Of Linear MRNA RNA Processing MRNA Processing Circadian Rhythm RNA Splicing Regulation Of Gene Expression Negative Regulation Of Translation Cell Differentiation Pancreas Development Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Glucose Homeostasis Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Circadian Regulation Of Translation	MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Interacting Genes		97 interacting genes: AQR CCNA1 CDK2 DDX17 DDX5 DHX9 ESS2 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 KLHL41 LRP2BP MAPK8IP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR17 MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PABPC1 PRPF31 PTBP2 PTEN RBM10 RBM22 RBM23 RBM42 RBM7 RNF10 SF1 SF3B4 SMAD5 SNRPC STEEP1 SURF6 TRIB3 U2AF2	100 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF6 CPSF7 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 ELAC1 EPRS1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PATL1 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM14 RBM17 RBM4 RBM45 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRIM25 TRIM56 TRIM71 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3
Entrez ID		5936	407014
HPRD ID		03982
Ensembl ID		ENSG00000173933	ENSG00000207547
Uniprot IDs		Q9BWF3
PDB IDs		2DNQ
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration MRNA Splicing, Via Spliceosome Negative Regulation Of Signal Transduction RNA Splicing, Via Transesterification Reactions Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Motility	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm Post-transcriptional Regulation Of Gene Expression Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Ribonucleoprotein Complex Catalytic Step 2 Spliceosome Cytoplasmic Stress Granule Regulation Of Translation MiRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation Ligase Activity MRNA Stabilization Negative Regulation Of Metabolic Process P-body
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