RBM4 and RBM22

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		RBM4	RBM22
Gene Name		RNA binding motif protein 4	RNA binding motif protein 22
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytoplasmic Stress Granule Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding MiRNA Binding Poly(A) RNA Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding	Nucleotide Binding Nucleocytoplasmic Transporter Activity SnRNA Binding Pre-mRNA Binding Poly(A) RNA Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation RNA Processing MRNA Processing RNA Splicing Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Translational Initiation Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Circadian Regulation Of Translation	Protein Import Into Nucleus, Translocation MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Cellular Response To Drug MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Intracellular Protein Transport
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Protein-Protein Interactions		29 interactors: AQR CCNA1 CDK2 CXorf56 DDX17 DDX5 DGCR14 DHX9 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 LRP2BP PABPC1 PRPF31 PTBP2 RBM10 RBM22 RBM23 RBM42 RBM7 SF1 SF3B4 SMAD5 SNRPC TRIB3 U2AF2	9 interactors: AQR CEP55 HNRNPUL1 PRNP RBFOX2 RBM4 RNU6-1 RNU6-50P RNU6-6P
Entrez ID		5936	55696
HPRD ID		03982	10186
Ensembl ID		ENSG00000173933	ENSG00000086589
Uniprot IDs		Q9BWF3	Q9NW64
PDB IDs		2DNQ	2YTC
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nitrogen Compound Metabolic Process MRNA Splice Site Selection Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway MRNA Cis Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Biogenesis MRNA Stabilization Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Meiotic Cell Cycle Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Negative Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Translational Initiation Cap-independent Translational Initiation Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Circadian Regulation Of Translation Cellular Response To Copper Ion Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Negative Regulation Of Interleukin-17 Production Cytoplasmic Translational Initiation Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Activated T Cell Proliferation RNA Metabolic Process Cytoplasmic Translation Regulation Of Translation In Response To Stress Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Negative Regulation Of Translational Initiation Negative Regulation Of T Cell Receptor Signaling Pathway Gene Expression Response To Copper Ion Entrainment Of Circadian Clock By Photoperiod Copper Ion Homeostasis Cell Migration In Hindbrain Photoperiodism Entrainment Of Circadian Clock Response To Arsenic-containing Substance Response To External Stimulus Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Interferon-gamma Production Gene Silencing By MiRNA Regulation Of Activated T Cell Proliferation Regulation Of Erythrocyte Differentiation Regulation Of Potassium Ion Transmembrane Transport Neuron Projection Morphogenesis Posttranscriptional Gene Silencing
Tagcloud ?		ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Difference) ?		ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Intersection) ?